Korean Journal of Gastrointestinal Endoscopy 2005;31(1): 32-38.
대장내시경 검사에서 Propofol을 이용한 Patient-Controlled Sedation과 Nurse-Administered Sedation의 효과 비교 연구
오지현·조 훈·김영묵·이무열·안광순·김현정·정현광·김강민·이준상
왈레스기념 침례병원 소화기내과
Patient-Controlled Sedation versus Nurse-Administered Sedation with Propofol during Colonoscopy
Jee Hyun Oh, M.D., Hoon Cho, M.D., Yeung Muk Kim, M.D., Mu Yeul Lee, M.D., Guang Soon An, M.D., Hyun Jeung Kim, M.D., Hyun Gwang Jung, M.D., Kang Min Kim, M.D. and Joon Sang Lee, M.D.
Department of Gastroenterology, Wallace Memorial Baptist Hospital, Busan, Korea
Abstract
Background/Aims: Patient-controlled sedation (PCS) allows the patients to titrate the dosages of sedative drug according to their needs. The objective of this study was to compare the safety and the efficacy of nurse-administered propofol sedation (NAPS) with those of PCS. Methods: Eighty one patients were randomly assigned to two groups. All patients received meperidine 25 mg and propofol 40 mg as an initial dose for sedation. Patients in PCS group were subsequently infused with propofol 15 mg over 80 seconds through infusion pump whenever they required. Patients in NAPS group were injected with 10∼20 mg propofol by nurse with supervision by endoscopist. The dosage of propofol, cardiopulmonary parameters, procedure time, sedation score, pain score, the patients' and endoscopists' satisfaction scores were assessed. Results: With regard to blood pressure, pulse rate and oxygen saturation, serious complications were not observed. Especially, there was no significant difference of mean total dose between two groups (NAPS group and PCS group received 76.7⁑24.7 mg and 82.5⁑26.6 mg respectively). Pain score was higher in woman than in man (p=0.03). Conclusions: 1.2∼1.5 mg/kg of propofol with small dose of opioid during colonoscopy was effective and safe. NAPS was more practical and useful method of sedation than PCS during colonoscopy. (Korean J Gastrointest Endosc 2005;31:3238)
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