Korean Journal of Gastrointestinal Endoscopy 2007;34(1): 9-13.
위의 이형성 및 선암종에서 변이형 p53 단백, p21waf1/cip1, Cyclin D1 발현 양상
윤기중 · 김헌수 · 조향정 · 최석채*
원광대학교 의과대학 병리학교실, *내과학교실
Expression of Mutant p53 Protein, p21waf1/cip1 and Cyclin D1 in Dysplasia and Adenocarcinoma of Stomach
Ki Jung Yun, M.D., Hun Soo Kim, M.D., Hyang Jeong Jo, M.D. and Suck Chei Choi, M.D.*
Departments of Pathology and *Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea
Abstract
Background/Aims: Gastric carcinoma is a major cause of morbidity and mortality in Korea. It evolves through dysplasia to an invasive adenocarcinoma. The carcinogenesis of dysplasia and adenocarcinoma in the stomach was investigated by examining the levels of mutant p53 protein, p21waf1/cip1, and cyclin D1 expression in gastric dysplasia and invasive adenocarcinoma. Methods: Formalin- fixed paraffin-embedded tumors were examined immunohistochemically using the monoclonal antibodies to the 53 protein, p21waf1/cip1 and cyclin D1. Results: Mutant p53 protein, p21waf1/cip1 and cyclin D1 expression were found in 66.6% (12/18), 72.2% (13/18) and 33.8% (6/18) of dysplasia, and 45.0% (9/20), 15.0% (3/20) and 30.0% (6/20) of invasive adenocarcinoma, respectively. Conclusions: These results suggest that p21waf1/cip1, which is controlled by the p53 protein, plays a more important role in the carcinogenesis of the stomach than cyclin D1.
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