| 식도 점막을 침범한 보통 천포창 1예 |
| 김영철·정우철·강석진*·홍창균·이강문·양진모·김재광·한석원·최규용·정인식 |
| 가톨릭대학교 의과대학 내과학교실, *임상병리학교실 |
| A Case of Esophageal Involvement in Pemphigus Vulgaris |
| Young Chul Kim, M.D., Woo Chul Chung, M.D., Seok Jin Kang, M.D.*, Chang Kyun Hong, M.D., Kang Moon Lee, M.D., Jin Mo Yang, M.D., Jae Kwang Kim, M.D., Sok Won Han, M.D., Kyu Yong Choi, M.D. and In-Sik Chung, M.D. |
| Departments of Internal Medicine and *Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea |
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| Abstract |
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Pemphigus vulgaris is a rare chronic disorder that is characterized by the development of bullae on the skin and mucous membrane due to an acantholysis mediated by circulating autoantibodies. It begins as painful, non- healing ulcerations in the mouth. After a period of weeks to months, the condition progresses to the skin. Occasionally, skin lesions may develop as the initial manifestation of this disease. However, esophageal involvement of pemphigus vulgaris is rare. An 84-year-old man was referred due to chest pain, dysphagia, oral ulcerations and facial bullae. The histopathological findings showed a suprabasal blister and acantholysis in the epithelium of the facial skin. An endoscopic examination revealed exfoliated erosions, ulcerations and hemorrhagic bullae on the oral and esophageal mucosa. The patient was started on high dose of corticosteroids and azathioprine, but there was no clinical improvement. The use of cyclophosphamide led to the remission of the lesions. (Korean J Gastrointest Endosc 2007;35:159-164) |
| Key Words:
Pemphigus vulgaris, Esophagus, Hemorrhagic bullae |
| 주요어:
보통 천포창, 식도, 출혈성 수포 |
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