Korean Journal of Gastrointestinal Endoscopy 2007;35(5): 313-320.
대장 선종 및 대장 선암에서 TGF-β1, 제2형 TGF-β 수용체 및 VEGF 단백의 면역조직화학적 발현
강상범ㆍ이승우ㆍ김연수ㆍ남순우ㆍ이동수ㆍ김진만*ㆍ한석원ㆍ최규용
가톨릭대학교 의과대학 내과학교실, *충남대학교 의과대학 병리학교실
Expression of TGF-β, TGF-β Receptor Type II and VEGF in Colorectal Adenomas and Adenocarcinomas
Sang Bum Kang, M.D., Seung Woo Lee, M.D., Yeon Soo Kim, M.D., Soon Woo Nam, M.D., Dong Soo Lee, M.D., Jin Man Kim, M.D.*, Sok Won Han, M.D. and Kyu Yong Choi, M.D.
Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, *Department of Pathology, College of Medicine, Chungnam National University, Daejeon, Korea
Abstract
Background/Aims: The aim of study was to investigate the expression of TGF-Ղ, TGF-RII and VEGF determined by immunohistochemical analysis with a comparison of the clinicopathological parameters such as tumor size, grade of dysplasia, lymph node metastasis and Dukes' stage in colorectal adenomas and adenocarcinomas, by use of a tissue microarray method. Methods: The expression of TGF-Ղ1, TGF-ՂRII, and VEGF was determined by immunohistochemistry in 20 adenomas and 40 adenocarcinomas. Tissue microarrays consisting of 2 mm cores from corresponding blocks were constructed and stained. Results: In adenomas, the staining intensity of TGF-Ղ, TGF-ՂRII and VEGF was increased in a high-grade dysplasia group of patients as compared a with low-grade dysplasia group of patients, respectively. The staining intensity of TGF-ՂRII was significantly increased in a high-grade dysplasia group of patients than a low-grade dysplasia group of patients (p =0.021). For the adenocarcinomas, the expression and staining intensity of TGF-Ղ1, TGF-ՂRII and VEGF were increased as compared with the adenomas (p＜0.001). However, no significant correlation was observed between the staining intensity of TGF-Ղ, TGF-ՂRII and VEGF and the clinicopathological parameters. Conclusions: The increased expression of TGF-Ղ1, TGF-ՂRII and VEGF in colorectal adenocarcinoma suggests a role for these proteins in colorectal carcinogenesis. Loss of the growth-inhibitory effect of TGF-Ղ may commence in the early stage of colorectal carcinogenesis. (Korean J Gastrointest Endosc 2007;35:313-320)
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