Korean Journal of Gastrointestinal Endoscopy 2009;38(1): 47-51.
항결핵제를 유지하면서 치료한 항결핵제 유발 위막성 대장염 치험 1예
우명렬ㆍ조재희ㆍ김정훈ㆍ김명환ㆍ권혁진ㆍ왕길상ㆍ이상엽*ㆍ조현근
관동대학교 의과대학 내과학교실 소화기내과, *병리학교실
Anti-Tuberculosis Agents Induced Pseudomembranous Colitis Treated with Maintaining Anti-Tuberculosis Drugs
Myoung Lyeol Woo, M.D., Jae Hee Cho, M.D., Jeong Hun Kim, M.D., Myoung Hwan Kim, M.D., Hyuk Jin Kwon, M.D., Kil Sang Wang, M.D., Sang Yeop Yi, M.D.* and Hyeon Geun Cho, M.D.
Division of Gastroenterology, Department of Internal Medicine and *Pathology, College of Medicine, Kwandong University, Goyang, Korea
Abstract
Tuberculosis is one of the main infectious health problems in Korea, and a combination of antibiotics is required to treat this illness. The combination therapy with rifampicin, isoniazid, ethambutol and pyrazinamide has many adverse reactions and there have been several case reports about pseudomembranous colitis (PMC) after anti- tuberculosis treatment. Rifampicin is regarded as a main cause of anti-tuberculosis induced PMC because of its bacteriocidal effect, and interruption of the offending drug, such as rifampicin, is usually necessary to treat the PMC. However, in patents with uncompensated tuberculosis, the discontinuance of anti-tuberculosis medication accentuates the disease severity, and continuance of the anti-tuberculosis medication is necessary to overcome the tuberculosis. We report here on a case in which the anti- tuberculosis agents induced PMC in 32 year old female who was diagnosed with active pulmonary tuberculosis. She was treated with maintenance of the anti-tuberculosis medication and also the addition of both oral metronidazole and probiotics. (Korean J Gastrointest Endosc 2009;38:47-51)
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