Korean Journal of Gastrointestinal Endoscopy 2009;39(6): 379-383.
아스피린과 비스테로이드성 소염제로 인한 다발성 위장관 궤양 출혈: 약제 기인성 대장 궤양을 중심으로 한 증례 보고와 문헌 고찰
김현진ㆍ정우철ㆍ이강문ㆍ백창렬ㆍ정승혜ㆍ김진동ㆍ정성훈ㆍ곽재욱
가톨릭대학교 의과대학 내과학교실
Multiple Gastrointestinal Drug Induced Ulcers Associated with Aspirin and Non-steroidal Anti-inflammatory Drugs: A Case Report and Review of the Literature
Hyun Jin Kim, M.D., Woo Chul Chung, M.D., Kang Moon Lee, M.D., Chang Nyol Paik, M.D., Seung Hye Jung, M.D., Jin Dong Kim, M.D., Sung Hoon Jung, M.D. and Jae Wuk Kwak, M.D.
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
Abstract
Aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed drugs, and they are known to be responsible for many cases of gastroduodenal ulcerations by inhibiting prostaglandin synthesis via blocking the cyclo-oxygenase production. Colonic side effects of these drugs are rare, but they are increasingly being reported to be due to the popularization of colonoscopy and the new formulations of drugs such as enteric coated pills or slow release pills. There is currently no consensus for making the clinical diagnosis and administering the proper therapy for drug-induced colonopathy in Korea. We experienced the patient who had multiple colonic ulcers after ingesting large amounts of aspirin and NSAIDs. In near future, we hope to determine the clinical and endoscopic features of drug associated colon injury. (Korean J Gastrointest Endosc 2009;39:379-383)
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