Korean J Gastrointest Endosc > Volume 41(1); 2010 > Article
Korean Journal of Gastrointestinal Endoscopy 2010;41(1): 10-15.
대장내시경 시행시 항콜린제 사용의 유용성
김은옥ㆍ이석호ㆍ김덕수ㆍ이창균ㆍ이태훈ㆍ정일권ㆍ박상흠ㆍ김선주
순천향대학교 의과대학 천안병원 내과학교실
A Clinical Usefulness of Premedication with Hyoscine N-butyl Bromide in Colonoscopy
Eun Ok Kim, M.D., Suck-Ho Lee, M.D., Duk Su Kim, M.D., Chang Kyun Lee, M.D., Tae Hoon Lee, M.D., Il-Kwun Chung, M.D., Sang-Heum Park, M.D. and Sun-Joo Kim, M.D.
Department of Internal Medicine, Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea
Abstract

Background/Aims:
We conducted a prospective, randomized, double-blinded, placebo-controlled trial to investigate the effect of hyoscine-N-butyl bromide during colonoscopy.
Methods:
A total of 133 patients undergoing colonoscopy were randomized to receive either 20 mg of hyoscine-N-butyl bromide (n=70) or normal saline solution (n=63) via intramuscular injection as premedication.
Results:
The mean cecal intubation time and withdrawal time in the hyoscine- N-butyl bromide group were significantly shorter than those of the control group (5.26±2.78 min vs. 6.74±4.89 min; p=0.032, 5.42±1.54 min vs. 6.18±2.54 min; p=0.038, each). The spasm grade in the hyoscine-N-butyl bromide group was significantly lower than that of the control group (p<0.001). No significant differences were found in the polyp detection rate (15.7% vs. 28.6%; p=0.073) and adenoma detection rate (10.0% vs. 15.9%; p=0.311). Difficulty of colonoscopy for the endoscopists and nurses (p=0.853; p=0.732), the patient's comfort (p=0.891) and the patient's willingness to repeat colonoscopy (85.7% vs. 82.5%; p=0.932) were also similar in both groups.
Conclusions:
Premedication with intramuscularly administered hyoscine-N-butyl bromide do not demonstrate any additional benefits except reducing the colonoscopy insertion time. (Korean J Gastrointest Endosc 2010;41:10-15)
Key Words: Colonoscopy, Premedication, Antispasmodics, Hyoscine-N-butyl bromide
주요어: 대장내시경, 전처치, 진경제, Hyoscine N-butyl bromide
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