Gastrointestinal lymphoma is the leading cause of extranodal lymphoma. Gastric lymphoma is very common in patients with gastrointestinal lymphoma, and diffuse large B-cell lymphoma and marginal zone B-cell lymphoma of the mucosa- associated lymphoid tissue (MALT) are the most common histological types. Helicobacter pylori (H. pylori) has been implicated in the pathogenesis of MALT lymphoma, and eradication of H. pylori has successfully resulted in the remission of MALT lymphoma. In the cases of H. pylori-negative MALT lymphoma or advanced gastric lymphoma, radiation therapy and/or chemotherapy can be used to treat the disease and achieve remission. (Korean J Gastrointest Endosc 2010;41:1-4)