Propofol, Endoscopy, Gastrointestinal, Aged"/>
The Adequate Induction Dose of Propofol for Conscious Sedation During Esophagogastroduodenoscopy in Persons 60 Years or Older
Korean Journal of Gastrointestinal Endoscopy 2010;41(3): 134-139.
60세 이상의 노인에서 의식하 진정 상부 위장관 내시경 검사시 Propofol의 적정 유도 용량
문형철ㆍ홍건영ㆍ김두진ㆍ최상철ㆍ박상욱ㆍ임연근
광주기독병원 내과
The Adequate Induction Dose of Propofol for Conscious Sedation During Esophagogastroduodenoscopy in Persons 60 Years or Older
Hyeung Cheol Moon, M.D., Gun Young Hong, M.D., Du Jin Kim, M.D., Sang Chul Choi, M.D., Sang Wook Park, M.D. and Yeun Keun Lim, M.D.
Department of Internal Medicine, Kwangju Christian Hospital, Gwangju, Korea
Abstract
Background/Aims: Propofol is an effective sedative drug in endoscopic procedures, but it has potentially serious adverse effects, so close monitoring of the vital signs should be performed during endoscopy. This study was undertaken to determine the adequate induction dose of propofol for safe and effective sedation during esophagogastrodudenoscopy (EGD) in persons 60 years or older.
Methods: Three hundred patients who visited our hospital for EGD were randomly assigned to three groups (A,B and C). An initial induction dose of 0.5 mg/kg, 0.75 mg/kg and 1.0 mg/kg of propofol was allocated to groups A, B and C, respectively.
Results: The 0.5 mg/kg, 0.75 mg/kg and, 1 mg/kg dose of propofol were all safe as an initial dose of propofol for achieving sedation during EGD in persons 60 years or older. There was no difference in the total amount of propofol among the three groups. Group C had a significantly shorter induction time and a lower dose was required for an additional injection of propofol without increasing adverse events, as compared to the two other groups.
Conclusions: We suggest that 1 mg/kg of propofol is an effective induction dose for sedation during EGD in persons 60 years or older. (Korean J Gastrointest Endosc 2010;40:134-139)
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