Hilar cholangiocarcinoma, Photodynamic therapy, Survival"/> The Long-term Outcome and Predictors for Increased Survival after PDT for Hilar Cholangiocarcinoma
Korean J Gastrointest Endosc > Volume 42(1); 2011 > Article
Korean Journal of Gastrointestinal Endoscopy 2011;42(1): 6-10.
간문부 담관암에서 광역학 치료의 장기 성적 및 생존율 향상에 미치는 인자
안지호ㆍ천영국ㆍ조영덕ㆍ최현종ㆍ문종호ㆍ이태훈ㆍ박상흠ㆍ심찬섭*
순천향대학교 의과대학 내과학교실, 소화기연구소, *건국대학교 의과대학 내과학교실 소화기병센터
The Long-term Outcome and Predictors for Increased Survival after PDT for Hilar Cholangiocarcinoma
Ji Ho Ahn, M.D., Young Koog Cheon, M.D., Young Deok Cho, M.D., Hyun Jong Choi, M.D., Jong Ho Moon, M.D., Tae Hoon Lee, M.D., Sang Heum Park, M.D. and Chan Sup Shim, M.D.*
Department of Internal Medicine, Institute for Digestive Research, Soonchunhyang University College of Medicine, *Digestive Disease Center, Konkuk University College of Medicine, Seoul, Korea
Abstract

Background/Aims:
Photodynamic therapy (PDT) has a promising effect on nonresectable cholangiocarcinoma (CC) but its long term data is not yet available. This study examined the long term outcome and factors associated with increased survival after performing PDT for hilar cholangiocarcinoma.


Methods:
A list of 393 patients with a diagnosis of hilar CC was retrieved from the database of Soonchunhyang University Hospital (Seoul, Korea) and these patients were seen from January 1, 2001, to April 1, 2010. We retrospectively reviewed the records of 74 patients who underwent PDT in addition to biliary stenting with/without chemoradiation.


Results:
The median overall survival from the date of diagnosis to death or to the last follow-up was 11.7 months (range: 2.2∼78.4). After performing PDT, a complete remission was observed in 1.3% (1/74) of the patients who had a superficial depth of tumor without lymph node involvement. On multivariate analysis using the Cox regression model, increasing the time to treatment after the diagnosis was a statistically significant predictor of shorter survival after PDT [Odds ratio: 3.25, 95% confidence interval (CI): 1.90∼4.71, p=0.034].


Conclusions:
Although PDT does not prevent progression of CC, it appears to control the cholestasis. The early treatment of PDT after the diagnosis showed a survival benefit for patients with advanced hilar CC. (Korean J Gastrointest Endosc 2011;42:6-10)

Key Words: Hilar cholangiocarcinoma, Photodynamic therapy, Survival
주요어: 간문부 담관암, 광역학 치료, 생존율
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