Korean Journal of Gastrointestinal Endoscopy 2011;42(3): 161-164.
메틸렌 블루 용액에 의한 급성 식도점막 손상 1예
고옥배ㆍ김도훈ㆍ강정민ㆍ정훈용
울산대학교 의과대학 서울아산병원 소화기내과학교실
Methylene Blue Solution-induced Acute Esophageal Mucosal Injury: First Case Report
Ock Bae Ko, M.D., Do Hoon Kim, M.D., Jung-Min Kang, M.D. and Hwoon-Young Jung, M.D.
Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Abstract
Methylene blue (MB) based chromoendoscopy has been used for more than a decade to increase detection rates of specialized intestinal metaplasia, dysplasia, and esophageal adenocarcinoma. It is also used to detect anastomotic leakage after an operation. A 67-year-old man with no previous medical problems had complaints of jaundice and weight loss for 2 months. He was diagnosed with a Klatskin tumor and was referred to our hospital. An initial esophagogastroduodenoscopy (EGD) was performed before the operation. No abnormality was observed in the esophagus. MB solution was infused via an L-tube to check for leakage in the anastomosis. Subepithelial hemorrhagic and edematous mucosal changes with friability and a bluish mucosal discoloration were noted 2 days later from the mid to lower esophagus on EGD. Nine months later, an EGD revealed an unremarkable esophageal mucosa. MB solution is considered safe; however, a large volume or high concentration of MB solution might be harmful. (Korean J Gastrointest Endosc 2011;42:161-164)
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