Endoscopic Ultrasonography Can Prevent Unnecessary Diagnostic Endoscopic Retrograde Cholangiopancreatography Even in Patients with High Likelihood of Choledocholithiasis and Inconclusive Ultrasonography: Results of a Prospective Study

Ruchir Patel; Meghraj Ingle; Dhaval Choksi; Prateik Poddar; Vikas Pandey; Prabha Sawant

doi:10.5946/ce.2017.010

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Original Article Endoscopic Ultrasonography Can Prevent Unnecessary Diagnostic Endoscopic Retrograde Cholangiopancreatography Even in Patients with High Likelihood of Choledocholithiasis and Inconclusive Ultrasonography: Results of a Prospective Study: Ruchir Patel^,, Meghraj Ingle, Dhaval Choksi, Prateik Poddar, Vikas Pandey, Prabha Sawant; Clinical Endoscopy 2017;50(6):592-597.
DOI: https://doi.org/10.5946/ce.2017.010
Published online: August 9, 2017

Department of Gastroenterology, Lokmanya Tilak Municipal Medical College and Hospital, Mumbai, India

Correspondence: Ruchir Patel Department of Gastroenterology, Lokmanya Tilak Municipal Medical College and Hospital, 1st Floor, College Building, Sion, Mumbai 400022, India Tel: +91-75-0606-5561, Fax: +91-22-2406-3088, E-mail: ruchir.cn@gmail.com

• Received: December 26, 2016 • Revised: March 18, 2017 • Accepted: May 11, 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSIONS
NOTES
Acknowledgments
REFERENCES

See letter "Can Endoscopic Ultrasonography Prevent Unnecessary Endoscopic Retrograde Cholangiopancreatography in Patients with High and Intermediate Likelihood of Choledocholithiasis?" in Volume 50 on page 518.

Abstract

Background/Aims
Endoscopic retrograde cholangiopancreatography (ERCP) is the initial therapy recommended for patients with high likelihood of choledocholithiasis. To determine whether endoscopic ultrasonography (EUS) can prevent diagnostic ERCPs in patients with high probability of choledocholithiasis and inconclusive ultrasonography (US).
Methods
All patients with high likelihood of choledocholithiasis and negative US underwent EUS. ERCP was performed for the patients who showed a definite stone/sludge on EUS. Patients without choledocholithiasis were followed up for 3 months. The primary outcome was avoidance of diagnostic ERCP.
Results
We included 78 patients (51 women; 27 men). Of these, 25 and 7 (total 41%) were diagnosed with choledocholithiasis and sludge, respectively; stone/sludge was removed in 96.9% of the patients. EUS ruled out choledocholithiasis in 38 patients (48.7%). Two of them were found to have choledocholithiasis on follow-up. The sensitivity, specificity, positive and negative predictive value of EUS for detecting choledocholithiasis were 93.9%, 97.3%, 96.9%, and 94.7%, respectively. Unnecessary ERCP was avoided in 57.7% of the patients by using the EUS-first approach.
Conclusions
EUS is a highly accurate and safe procedure. EUS can replace ERCP as the initial investigation in patients with a high probability of choledocholithiasis. It avoids unnecessary ERCP; hence, decreasing related costs and complications.
Keywords: Endosonography; High likelihood; Choledocholithiasis; Unnecessary endoscopic retrograde cholangiopancreatography; Inconclusive imaging

INTRODUCTION

Choledocholithiasis can occur in 3%–16% of patients with gallbladder stones [1,2]. It can be present in 10%–20% of patients undergoing cholecystectomy and in 18%–21% of those with gallstone pancreatitis [3]. Many studies over the past decade have shown that endoscopic ultrasonography (EUS) is highly sensitive and its accuracy is comparable with endoscopic retrograde cholangiopancreatography (ERCP) in detecting common bile duct (CBD) stones [4-7]. EUS has been shown to be more sensitive and specific than other noninvasive modalities such as abdominal ultrasonography (US), abdominal computed tomography (CT), and magnetic resonance cholangiopancreatography (MRCP) [8,9]. Thereby, it is postulated that EUS can prevent unnecessary diagnostic ERCP and its complications in patients with suspected CBD stone.

The recent American Society for Gastrointestinal Endoscopy (ASGE) practice guideline suggests a stratified approach to investigate suspected choledocholithiasis based on the three likelihood categories: high, intermediate, and low [10]. An ample number of studies showed EUS to be the preferred modality in patients with an intermediate probability of having a CBD stone [11-13]. However, for the high-probability patients, studies that directly compared EUS with ERCP are rare. Awaiting the data, ERCP remains the recommended initial therapy for the high-probability group [10].

Therefore, the aim of our study was to assess whether EUS can avoid unnecessary diagnostic ERCPs in patients with a high likelihood of choledocholithiasis and negative imaging.

MATERIALS AND METHODS

Study design

This was a single-center prospective study conducted in the department of gastroenterology at a large tertiary care referral center in Western India. The study was approved by the institutional ethics committee and followed the ethical guidelines of the Declaration of Helsinki. Our hospital has a large referral gastrointestinal endoscopy unit that handles approximately 500 EUS and 400 ERCPs annually. All the patients admitted under the suspicion of choledocholithiasis or referred for EUS for the same indication between March 2015 and July 2016 were screened. Patients who fulfilled the inclusion criteria were enrolled in the study cohort. Written informed consent was sought from all the patients. Data on demographic characteristics; clinical features; blood biochemical tests, including liver function tests (LFT); and US findings were collected. All the patients underwent EUS first. EUS features consistent with stone or sludge were termed as a positive EUS result. ERCP with sphincterotomy and stone extraction were performed for patients with positive EUS results. Those with a negative EUS result were followed up for at least 3 months by clinical evaluation every 15 days, LFT weekly until normalization, and repeat US if required. ERCP and stone removal were performed if a CBD stone was detected during follow-up. EUS findings other than choledocholithiasis were also noted and managed in accordance with the diagnosis. The study protocol and enrolment of the patients are shown in Fig. 1.

Patient selection

The patients who presented with symptoms of biliary colic were included in the study if they had inconclusive imaging and any one of the following ASGE criteria suggestive of high clinical likelihood of choledocholithiasis [10]: symptoms consistent with cholangitis, bilirubin level of >4 mg/dL, and dilated CBD on US (≥6 mm; ≥10 mm if post-cholecystectomy status), with a bilirubin level of 1.8–4 mg/dL or suspicious CBD stone on imaging. Inconclusive imaging meant abdominal US that failed to show the cause of biliary obstruction. CT or MRCP was not mandatory for the inclusion of patients. The exclusion criteria for the study were patients aged <18 years, pregnancy, previously diagnosed biliary pathology other than choledocholithiasis, patients with a low performance status who were considered high-risk for sedation by an anesthetist, and those not willing to provide informed consent.

Procedures

All EUS procedures were performed by a single expert endoscopist (MI) with >3 years of experience in the field of diagnostic and therapeutic EUS. The procedures were carried out by using a linear echoendoscope (GF-UCT180; Olympus Medical, Tokyo, Japan) under conscious sedation with intravenous midazolam and pentazocine. EUS was performed from the gastroesophageal junction, antrum, and first and second parts of the duodenum for complete CBD evaluation. CBD stone was characterized by echogenic focus in the bile duct with acoustic shadowing, while sludge manifests as a layering echogenic material without shadows. Therapeutic ERCP was performed by using a side-viewing ERCP scope (TJF-150; Olympus Medical, Tokyo, Japan) by the same endoscopist under the same sedation in case of positive EUS findings. The procedure steps included bile duct access with guide wire by using a biliary sphincterotome, contrast injection in CBD to locate the stone or sludge, biliary sphincterotomy, and stone or sludge extraction by using a stone extraction balloon catheter followed by 7- or 10-F biliary plastic stent placement. EUS and ERCPs were performed by a single experienced endoscopist to minimize variation in procedure results as both ERCP and especially EUS are highly operator dependent.

Study outcomes

The primary outcome of the study was avoidance of unnecessary diagnostic ERCP. The sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of EUS for detecting CBD stones were considered secondary outcomes. The laboratory and imaging parameters proposed in the high likelihood criteria were compared between the patients with and those without choledocholithiasis on EUS to validate their predictive accuracy. These results, along with the safety of EUS and ERCP procedures, were the additional outcomes of the study.

Statistical analysis

Descriptive data were assessed as mean and standard deviation (SD). The sensitivity, specificity, NPV, and PPV of EUS for detection of CBD stones were calculated by using the ERCP findings as the gold standard. Factors associated with CBD stones were assessed by using univariate analysis. Chi-square test or Fisher exact test, when the expected number of cells was <5, were applied to analyze categorical variables. On the other hand, non-parametric continuous variables were analyzed by using the Mann-Whitney U test; and parametric continuous data, by unpaired t test. A p-value of <0.05 was considered statistically significant. All statistical analyses were performed by using the SPSS version 17.0 software (SPSS Inc., Chicago, IL, USA).

RESULTS

Study cohort

The study cohort included 78 patients aged 45.5±15.1 years (mean±SD). Most of the patients were female (n=51, 66%). The numbers of patients who fulfilled the criteria of high likelihood of choledocholithiasis are shown in Table 1. All the patients had inconclusive US results. Among them, 56 (71.8%) had a dilated CBD. Bilirubin level was the most commonly deranged LFT component (95%). Detailed demographic and laboratory characteristics of the study population are shown in Table 2.

Primary and secondary outcomes

EUS detected choledocholithiasis in 25 patients (32.1%); and CBD sludge, in 7 patients (8.9%). The mean stone size was 8 mm (range, 4–15 mm). Subsequent ERCP extracted stone or sludge in 31 of the 32 patients (96.9%). EUS was used to rule out choledocholithiasis in 38 patients (48.7%). They were discharged and followed up for a minimum of 3 months, with a mean follow-up period of 4.2 months. In these patients, CBD stones were diagnosed during follow-up imaging in 2 patients who underwent ERCP, on follow-up day 10 in 1 patient, and on day 14 in 1 patient. LFT results were persistently elevated, and recurrent biliary colic appeared in both patients. The rest of the patients were symptom-free. The sensitivity and specificity of EUS for detecting CBD stone were 93.9% and 97.3%, respectively. EUS had a high predictive accuracy for detecting and ruling out stones in suspected choledocholithiasis, with a PPV of 96.9% and NPV of 94.7%. Diagnostic ERCPs were avoided in 45 patients (57.7%). Various EUS results are shown in Table 3.

Additional outcomes

The univariate analysis of the factors potentially associated with choledocholithiasis is shown in Table 4. Neither the laboratory parameters such as bilirubin (p=0.3), alanine aminotransferase (ALT; p=0.4), aspartate aminotransferase (AST; p=0.6), and alkaline phosphatase (ALP) levels (p=0.57) nor the imaging parameters such as dilated CBD on US (p=0.6) were significantly associated with the presence of choledocholithiasis.

Other etiologies

Apart from CBD stones, EUS also detected various other etiologies in 8 patients (10.3%). On EUS, malignant biliary obstruction was identified in 4 patients (5.2%). One of them had an ampullary carcinoma, 2 had a distal cholangiocarcinoma, and 1 had a carcinoma of the gallbladder neck. Two patients (2.6%) had extrinsic compression on CBD, 1 (1.3%) had roundworm infestation, and 1 (1.3%) had Mirizzi’s syndrome. None of the 8 patients had choledocholithiasis. Roundworm on EUS was detected as a hypoechoic linear structure with hyperechoic walls within the CBD without any acoustic shadowing. Roundworm was removed from the CBD by ERCP and balloon sweeps. The rest of the cases were managed in accordance with the diagnosis. Operable malignancies were referred for surgical exploration, and inoperable ones were treated accordingly.

Adverse events

No serious adverse events occurred during either the EUS or ERCP procedures. Although no head-to-head comparison was performed between EUS and ERCP, complications were less with EUS than with ERCP. All the adverse events were managed conservatively. The adverse events that occurred during the study are described in Table 5.

DISCUSSION

Several studies have invalidated the use of biochemical and imaging parameters to predict choledocholithiasis [14,15]. EUS is sensitive and highly accurate for diagnosing choledocholithiasis as compared with MRCP and ERCP, with up to 94% sensitivity and 95% specificity [8,9]. EUS remains highly sensitive for stones <5 mm, where the sensitivity of MRCP has been reported to be as low as 33%–71% [16,17]. Current guidelines still rely on a risk stratification approach for CBD stone based on various prognostic parameters. They recommend pre-procedure EUS or MRCP for patients with intermediate probability of choledocholithiasis and direct ERCP for the high-probability group [10]. Considering the relatively high rates of complications and invasive nature of ERCP, EUS has been proposed even in the high likelihood group to avoid unnecessary diagnostic ERCP.

The present study assessed the role of EUS for detection of CBD stone in the high-probability group. Only 41% of the patients categorized as high-risk according to the ASGE guideline actually had choledocholithiasis. This confirms the unreliability of the prognostic models in the high-probability group. Almost similar results were obtained in a study by Prachayakul et al. (38.68%) [11]. Several other studies also reported a stone detection rate of only up to 60% in high likelihood patients [18-20]. Unnecessary diagnostic ERCP was avoided in 57.7% of the patients by using the “EUS first” approach in the present study.

The sensitivity and specificity of EUS in detecting CBD stones in our study were 93.9% and 97.3%, respectively. Only 1 EUS showed a false-positive result, and 2 showed false-negative results. False-negative results were possibly attributed to a small size of stones. Prachayakul’s group showed 100% sensitivity and 80% specificity; however, it included both high- and intermediate-probability patients [11]. Another study showed a sensitivity and specificity of 91% and 100%, respectively, in the high-risk cohort [19]. The predictive accuracy of EUS in the present study was almost similar to that of others. The marginally lower sensitivity and predictive accuracy can be attributed to the relatively recent availability of EUS in our center and shorter experience of the endoscopists in performing EUS. Our study results were analogous to those of studies performed in larger EUS centers.

No significant association was found between any of the clinical, laboratory, or imaging parameters proposed in the high likelihood criteria and for choledocholithiasis in the present study. A randomized controlled trial (RCT) by Lee et al. found similar results [18]. However, one study showed an association of elevated ALP levels and positive results of EUS performed within 7 days of symptom onset [11]. A study from Italy showed only CBD diameter to be the independent predictor of choledocholithiasis [13]. The discordant results from multiple studies show the unreliability of the commonly used biochemical and radiological predictors of the presence of CBD stone even for high-probability groups. Therefore, we suggest that EUS should be performed in all cases of highly probable choledocholithiasis.

Few studies have also shown significant cost benefits of the “EUS first” approach in comparison with MRCP before ERCP or ERCP alone in patients with low to intermediate likelihood of choledocholithiasis [21]. The same approach can be applied to high likelihood patients in spite of the higher need for ERCP in this cohort. Although the present study did not perform a cost analysis, the “EUS first” approach might be less costly for high likelihood groups, considering the extremely high costs of unnecessary ERCP, hospital stay, unnecessary investigations, and medications. However, further studies are required to assess the cost-effectiveness in this cohort.

EUS detected various etiologies of biliary obstruction other than choledocholithiasis in 10.3% of cases. The high rate of alternative diagnosis can be ascribed to an inappropriate clinical history given by few patients who were referred for EUS in an outpatient basis. Those patients were managed in accordance with their diagnosis. Nevertheless, this shows the usefulness of EUS in the detection of other biliary diseases that might not be found on ERCP. All EUS procedures were performed without any complications.

This stud had a few limitations. First, it was not an RCT. Head-to-head comparison between EUS and ERCP was not performed, and the diagnostic accuracy of EUS was calculated and compared with that of ERCP as the gold standard. ERCP can yield false results, as it is operator and technology dependent. Second, the minimum follow-up period for patients with negative EUS results was only 3 months. Longer follow-up data can produce even more accurate results. Apart from that, newly migrated stones from the gallbladder during follow-up can produce similar symptoms as missed stones. However, persistently elevated LFT results and clinical evaluation in both patient groups differentiated the two conditions in favor of missed stones.

CONCLUSIONS

The present study confirms that EUS-guided ERCP is a highly accurate and safe strategy for the management of patients with high probability of CBD stone. EUS not only identifies patients who need ERCP but also safely avoids unnecessary diagnostic ERCP, hence reducing related potential complications and significant healthcare costs. We conclude that EUS should be considered routinely instead of ERCP in all patients with a high probability of suspected choledocholithiasis. ERCP should be reserved only for patients with positive EUS results.

Conflicts of Interest: The authors have no financial conflicts of interest.

Acknowledgments

We acknowledge Dr. Shantanu Kulkarni and all the residents from the Department of Anaesthesia, Lokmanya Tilak Medical College and Hospital, for their immense support throughout the study by administering conscious sedation in the patients who were to undergo EUS and ERCP.

Fig. 1.

Study protocol with details of the inclusion and exclusion criteria.

^a)Eight patients had alternative diagnosis on endoscopic ultrasonography (EUS).

Table 1.

Patient Distribution according to Various ASGE Criteria for High Probability of Choledocholithiasis

	Number of patients (n)	Percentage (%)
Patients with high likelihood of CBD stone	78	100
Dilated CBD with altered LFT	56	71.8
Bilirubin >4 mg/dL	19	24.4
Clinical cholangitis	3	3.8

ASGE, American Society for Gastrointestinal Endoscopy; CBD, common bile duct; LFT, liver function tests.

Table 2.

Clinical and Laboratory Characteristics of the Study Cohort

Patient characteristics	Total patients (n=78)
Male (n, %)	27 (34)
Female (n, %)	51 (66)
Age (mean±SD) (yr)	45.5±15.1
White cells (/mm³)(mean)	8,500
LFT (mean±SD)
Bilirubin (mg/dL)	3.4±3.8
ALT (U/L)	167±130
AST (U/L)	138±126
ALP (U/L)	368±256
Dilated CBD (n, %)	56 (71.8%)

SD, standard deviation; LFT, liver function tests; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; CBD, common bile duct.

Table 3.

EUS Findings of the Study

EUS findings	Number of patients (n)	Percentage (%)
CBD stone	25	32.1
CBD sludge	7	8.9
Negative EUS	38	48.7
Others	8	10.3
Cholangiocarcinoma	2	2.6
Ampullary Carcinoma	1	1.3
Carcinoma GB	1	1.3
Extrinsic compression	2	2.6
Round worm in CBD	1	1.3
Mirrizi’s syndrome	1	1.3

EUS, endoscopic ultrasonography; CBD, common bile duct; GB, gall bladder.

Table 4.

Univariate Analysis of the Factors Potentially Associated with Presence of Choledocholithiasis. Patients Who were Diagnosed with Other Etiologies on EUS (n=8) were Excluded from the Univariate Analysis

	Stone present (n=32)	Stone absent (n=38)	p-value
LFT (mean±SD)
Bilirubin (mg/dL)	3.8 (3.4)	3 (3.2)	0.3
ALT (U/L)	185 (161)	159 (119)	0.4
AST (U/L)	153 (123)	137 (132)	0.6
ALP (U/L)	397 (272)	362 (248)	0.57
Dilated CBD (n, %)	24 (75%)	26 (69%)	0.6

EUS, endoscopic ultrasonography; LFT, liver function tests; SD, standard deviation; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; CBD, common bile duct.

Table 5.

Adverse Events Seen with EUS and ERCP Procedures during the Study

Adverse event	EUS (n=78)	ERCP (n=33)
Pancreatitis	0	2
Bleeding	1	5
Hypoxia	1	3
Perforation	0	0
Cholangitis	0	0
Mortality	0	0
Sedation related complications	0	1

EUS, endoscopic ultrasonography; ERCP, endoscopic retrograde cholangiopancreatography.

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Endoscopic Ultrasonography Can Prevent Unnecessary Diagnostic Endoscopic Retrograde Cholangiopancreatography Even in Patients with High Likelihood of Choledocholithiasis and Inconclusive Ultrasonography: Results of a Prospective Study

Clin Endosc. 2017;50(6):592-597. Published online August 9, 2017

DOI: https://doi.org/10.5946/ce.2017.010

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Figure

Fig. 1. Study protocol with details of the inclusion and exclusion criteria. a)Eight patients had alternative diagnosis on endoscopic ultrasonography (EUS).

Fig. 1.

	Number of patients (n)	Percentage (%)
Patients with high likelihood of CBD stone	78	100
Dilated CBD with altered LFT	56	71.8
Bilirubin >4 mg/dL	19	24.4
Clinical cholangitis	3	3.8

Patient characteristics	Total patients (n=78)
Male (n, %)	27 (34)
Female (n, %)	51 (66)
Age (mean±SD) (yr)	45.5±15.1
White cells (/mm³)(mean)	8,500
LFT (mean±SD)
Bilirubin (mg/dL)	3.4±3.8
ALT (U/L)	167±130
AST (U/L)	138±126
ALP (U/L)	368±256
Dilated CBD (n, %)	56 (71.8%)

EUS findings	Number of patients (n)	Percentage (%)
CBD stone	25	32.1
CBD sludge	7	8.9
Negative EUS	38	48.7
Others	8	10.3
Cholangiocarcinoma	2	2.6
Ampullary Carcinoma	1	1.3
Carcinoma GB	1	1.3
Extrinsic compression	2	2.6
Round worm in CBD	1	1.3
Mirrizi’s syndrome	1	1.3

	Stone present (n=32)	Stone absent (n=38)	p-value
LFT (mean±SD)
Bilirubin (mg/dL)	3.8 (3.4)	3 (3.2)	0.3
ALT (U/L)	185 (161)	159 (119)	0.4
AST (U/L)	153 (123)	137 (132)	0.6
ALP (U/L)	397 (272)	362 (248)	0.57
Dilated CBD (n, %)	24 (75%)	26 (69%)	0.6

Adverse event	EUS (n=78)	ERCP (n=33)
Pancreatitis	0	2
Bleeding	1	5
Hypoxia	1	3
Perforation	0	0
Cholangitis	0	0
Mortality	0	0
Sedation related complications	0	1

Table 1. Patient Distribution according to Various ASGE Criteria for High Probability of Choledocholithiasis

ASGE, American Society for Gastrointestinal Endoscopy; CBD, common bile duct; LFT, liver function tests.

Table 2. Clinical and Laboratory Characteristics of the Study Cohort

SD, standard deviation; LFT, liver function tests; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; CBD, common bile duct.

Table 3. EUS Findings of the Study

EUS, endoscopic ultrasonography; CBD, common bile duct; GB, gall bladder.

Table 4. Univariate Analysis of the Factors Potentially Associated with Presence of Choledocholithiasis. Patients Who were Diagnosed with Other Etiologies on EUS (n=8) were Excluded from the Univariate Analysis

EUS, endoscopic ultrasonography; LFT, liver function tests; SD, standard deviation; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; CBD, common bile duct.

Table 5. Adverse Events Seen with EUS and ERCP Procedures during the Study

EUS, endoscopic ultrasonography; ERCP, endoscopic retrograde cholangiopancreatography.