1Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
2KM Biologics Co., Ltd., Kumamoto, Japan
Copyright © 2021 Korean Society of Gastrointestinal Endoscopy
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Conflicts of Interest: Yoshitaka Takegawa, Yuki Koga, Kazunori Yamanaka, Masataka Sagata work for KM Biologics Co., Ltd. The other authors have no potential conflicts of interest.
Funding
This research was conducted as a collaborative effort between Kobe University and KM Biologics Co., Ltd.
Author Contributions
Conceptualization: Hiroya Sakaguchi, Toshitatsu Takao, Yoshitaka Takegawa, Yuki Koga, Kazunori Yamanaka, Masataka Sagata
Data curation: HS, TTa, YT, YKog, KY, MS
Formal analysis: HS, TTa, YT, YKog, KY, MS
Funding acquisition: HS, TTa, YT, YKog, KY, MS
Investigation: HS, TTa, YT, YKog, KY, MS
Methodology: HS, TTa, YT, YKog, KY, MS
Project administration: HS, TTa, YT, YKog, KY, MS
Resources: HS, TTa, YT, YKog, KY, MS
Software: HS, TTa, YT, YKog, KY, MS
Supervision: HS, TTa, YT, YKog, KY, MS, Shinwa Tanaka, Yoshinori Morita, Takashi Toyonaga, Yuzo Kodama
Validation: HS, TTa, YT, YKog, KY, MS, ST, YM, TTo, YKod
Visualization: HS, TTa, YT, YKog, KY, MS, ST, YM, TTo, YKod
Writing-original draft: HS, TTa, YT, YKog, KY, MS
Writing-review&editing: HS, TTa, YT, YKog, KY, MS, ST, YM, TTo, YKod
Conventional method |
|||||
---|---|---|---|---|---|
Individual number | Ulcer number | Size of mucosal defect (major×minor axis), cm | Delivery and covering time (min, sec) | Size of mucosal defect (cm2) | Delivery and covering time per unit area (min/cm2) |
3 | 3 | 3.0×2.8 | 4 min 28 sec | 6.6 | 0.68 |
3 | 3 | 2.8×2.8 | 5 min 21 sec | 6.2 | 0.87 |
3 | 3 | 2.8×2.8 | 6 min 28 sec | 6.2 | 1.05 |
3 | 4 | 4.0×2.8 | 11 min 26 sec | 8.8 | 1.30 |
3 | 4 | 4.2×2.6 | 10 min 16 sec | 8.6 | 1.20 |
3 | 4 | 4.5×2.5 | 8 min 25 sec | 8.8 | 0.95 |
Envelope method |
|||||
Individual number | Ulcer number | Size of mucosal defect (major×minor axis), cm | Delivery and covering time (min, sec) | Size of mucosal defect (cm2) | Delivery and covering time per unit area (min/cm2) |
3 | 3 | 3.3×3.0 | 1 min 33 sec | 7.8 | 0.20 |
3 | 3 | 2.8×2.8 | 2 min 07 sec | 6.2 | 0.34 |
3 | 3 | 3.0×3.0 | 1 min 18 sec | 7.1 | 0.18 |
3 | 4 | 4.5×3.1 | 3 min 14 sec | 11.0 | 0.30 |
3 | 4 | 4.5×3.0 | 4 min 20 sec | 10.6 | 0.41 |
3 | 4 | 4.5×2.7 | 5 min 00 sec | 9.5 | 0.52 |
Conventional method |
|||||
---|---|---|---|---|---|
Individual number | Ulcer number | Size of mucosal defect (major×minor axis), cm | Delivery and covering time (min, sec) | Size of mucosal defect (cm2) | Delivery and covering time per unit area (min/cm2) |
1 | 1 | 3.6×3.3 | 11 min 07 sec | 9.3 | 1.19 |
1 | 1 | 3.7×3.0 | 9 min 52 sec | 8.7 | 1.13 |
1 | 1 | 4.1×3.0 | 11 min 42 sec | 9.7 | 1.21 |
2 | 2 | 3.6×3.2 | 14 min 42 sec | 9.0 | 1.63 |
2 | 2 | 3.6×3.6 | 15 min 55 sec | 10.2 | 1.56 |
2 | 2 | 4.0×3.9 | 14 min 07 sec | 12.2 | 1.15 |
Envelope method |
|||||
Individual number | Ulcer number | Size of mucosal defect (major×minor axis), cm | Delivery and covering time (min, sec) | Size of mucosal defect (cm2) | Delivery and covering time per unit area (min/cm2) |
1 | 1 | 3.6×3.3 | 4 min 41 sec | 9.3 | 0.50 |
1 | 1 | 3.8×3.3 | 4 min 52 sec | 9.8 | 0.49 |
1 | 1 | 4.3×3.6 | 7 min 06 sec | 12.2 | 0.58 |
2 | 2 | 4.5×3.9 | 6 min 38 sec | 13.8 | 0.48 |
2 | 2 | 4.2×4.0 | 5 min 07 sec | 13.2 | 0.39 |
2 | 2 | 4.2×3.7 | 6 min 56 sec | 12.2 | 0.57 |