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Original Article Insufflation of Carbon Dioxide versus Air During Colonoscopy Among Pediatric Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
John Alexander Lata Guacho1orcid, Diogo Turiani Hourneaux de Moura1,4orcid, Igor Braga Ribeiro1,orcid, Bruna Furia Buzetti Hourneaux de Moura2orcid, Megui Marilia Mansilla Gallegos3orcid, Thomas McCarty4orcid, Ricardo Katsuya Toma2orcid, Eduardo Guimarães Hourneaux de Moura1orcid
Clinical Endoscopy 2021;54(2):242-249.
DOI: https://doi.org/10.5946/ce.2020.275
Published online: March 25, 2021

1Gastrointestinal Endoscopy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

2Gastroenterology and Hepatology Pediatric Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

3Servicio de Gastroenterología, Clínica Maison de Sante del Sur Lima-Perú, Lima, Perú

4Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital, Boston, MA, USA

Correspondence: Igor Braga Ribeiro Gastrointestinal Endoscopy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255, Instituto Central, Prédio dos Ambulatórios, São Paulo, 05403-000, Brazil Tel: +55-92-98137-7788, Fax: +55-11-2661-6467, E-mail: igorbraga1@gmail.com
• Received: October 14, 2020   • Revised: January 26, 2021   • Accepted: February 1, 2021

Copyright © 2021 Korean Society of Gastrointestinal Endoscopy

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Background/Aims:
    Carbon dioxide is increasingly used in insufflation during colonoscopy in adult patients; however, air insufflation remains the primary practice among pediatric gastroenterologists. This systematic review and meta-analysis aims to evaluate insufflation using CO2 versus air in colonoscopies in pediatric patients.
  • Methods:
    Individualized search strategies were performed using MEDLINE, Cochrane Library, EMBASE, and LILACS databases following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and Cochrane working methodology. Randomized control trials (RCTs) were selected for the present meta-analysis. Pooled proportions were calculated for outcomes including procedure time and abdominal pain immediately and 24 hours post-procedure.
  • Results:
    The initial search yielded 644 records, of which five RCTs with a total of 358 patients (CO2: n=178 versus air: n=180) were included in the final analysis. The procedure time was not different between the CO2 and air insufflation groups (mean difference, 10.84; 95% confidence interval [CI], -2.55 to 24.22; p=0.11). Abdominal pain immediately post-procedure was significantly lower in the CO2 group (risk difference [RD], -0.15; 95% CI; -0.26 to -0.03; p=0.01) while abdominal pain at 24 hours post-procedure was similar (RD, -0.05; 95% CI; -0.11 to 0.01; p=0.11).
  • Conclusions:
    Based on this systematic review and meta-analysis of RCT data, CO2 insufflation reduced abdominal pain immediately following the procedure, while pain was similar at 24 hours post-procedure. These results suggest that CO2 is a preferred insufflation technique when performing colonoscopy in pediatric patients.
Over the last 30 years, gastrointestinal endoscopy in pediatric patients has been increasingly developed to improve its diagnostic and therapeutic utilities [1]. Colonoscopy procedures for children are mainly performed for those suspected of inflammatory bowel disease, rectal bleeding, genetic polyposis syndromes, anemia, and unexplained chronic diarrhea [1]. With fewer procedures performed in pediatrics compared to the adult population, mostly as a result of routine colorectal screening, careful consideration must be given regarding the procedure to achieve appropriate bowel preparation, reduce procedure-associated abdominal pain, safely administer anesthetic, and ensure cooperation among children and parents alike [2-9].
Since 1980, scientists have been investigating the impact of pain and pain relief among pediatric patients and the potential for negative physiological, emotional, and psychological ramifications [10-12]. These findings suggest not only immediate impact but also lasting effects that alter the quality of life and the long-term future of many at-risk children. Given this, the American Academy of Pediatrics and the American Pain Board recommended the safe use of analgesics and pain relief whenever possible in the appropriate clinical setting. For this reason, techniques to reduce abdominal pain during colonoscopy have been implemented, such as the use of sedatives, hypnotics, acupuncture, Yoga nidra, music therapy, and the use of carbon dioxide [13,14].
To date, novel advancements have been made in the diagnostic and therapeutic areas of endoscopy, including visualization of the intestinal mucosa and insufflation [15,16]. Rogers [17] conducted a small study that first reported on the benefit of using CO2 insufflation during colonoscopy, owing to the properties of fast absorption and improvement of adverse events caused by abdominal distention; since then CO2 has been used for a wide variety of endoscopic procedures [14,18–20]. However, evidence for the use of CO2 insufflation during colonoscopies among pediatric population remains scarce, with data largely extrapolated from adults. The main objective of this study was to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effectiveness of CO2 versus air insufflation in pediatric patients undergoing colonoscopy.
Protocol and registration
This systematic review and meta-analysis was conducted following the guidelines of the Cochrane handbook for systematic reviews of interventions and information Elements (PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Aanalyses) [21]. This research work has been registered in the Prospective International Registry of Continuous Systematic Reviews of the National Institutes for Health Research (PROSPERO) with the code CRD42020185384. It also has the approval of the Committee of Scientific Ethics of the Department of Gastroenterology of the Faculty of Medicine from the University of São Paulo.
Search and information sources
The search strategy was carried out in the following electronic databases: MEDLINE, Cochrane Library, EMBASE, and LILACS from the start date to December 2020. Only RCTs were included, regardless of language and year of publication. The terminologies used for the search were the following in Medline: “(CO2 OR CO 2 OR carbon dioxide OR air OR insufflation / methods*) AND (colonoscopy OR colonoscopic) AND (pediatric OR pediatrics OR child OR preschool)”. For other databases, the following search “Carbon Dioxide AND Air AND Colonoscopy” was used.
Eligibility criteria, study selection, and data items
RCTs using CO2 or air for colonoscopic insufflation in patients under 21 years old were included. Exclusion criteria were RCTs comprising patients with a history of cardiac health issues, acute pulmonary infections, chronic lung disease, oxygen-dependent pulmonary disease (such as bronchopulmonary dysplasia, severe asthma, or cystic fibrosis), mental disability, pregnancy, colon resection or stoma, known allergy to certain sedatives used during the procedure, inability to complete the visual analog scale or Wong-Baker Faces Scale, psychomotor impairment, or hemodynamic instability. Additionally, RCTs with patients undergoing colonic manometry were also excluded. Other exclusion criteria were case and series reports, editorial articles, and non-randomized studies (i.e., prospective or retrospective comparative studies). The outcomes measured in this study were the duration of the colonoscopy procedure, abdominal pain immediately after the procedure, and abdominal pain 24 hours after the procedure.
Data collection process and study selection
The information was collected from the selected clinical trials, contained in tables or graphs according to our results. Two independent investigators conducted the screening for eligibility with the criteria of inclusion and exclusion to our evaluation. Any disagreements were resolved by consensus or by consultation with a third reviewer. The data collected were type of study, patients by age, sex, total number, and indication of the examination.
Risk of bias
For the analysis of the risk of bias of the selected studies, using the Cochrane guidelines we assessed the adequate risk of bias exclusively for RCTs (Rob-2, risk-of-bias tool for RCTs), with the latest version updated on August 22, 2019 [22]. When our study was included, the risk of bias analysis program classified it into five domains: selection of the reported result, measurement of the outcome, missing outcome data, deviations from intended interventions, randomization process, and overall. In addition, the characteristics for each domain were classified as low risk (green color), some concerns (yellow color), and high risk (red color) (Supplementary File 1), with the risks of bias that are assessed for each outcome and globally as described in the Cochrane Rob-2 guideline [22]. We performed complete analyses of individual studies and across the studies.
Synthesis of results, data analysis and summary measures

The rating of the evidence

To qualify the evidence, it was evaluated using GRADEproGDT software (Mc Master University, Ontario, Canada). through objective analysis, according to the results of our study. GRADEproGDT is a software used to grade the evidence from included studies according to the following guidelines: number of studies, study design, risk of bias, imprecision, indirect evidence, inconsistency and other considerations, summary of findings, and importance.
The rating of the evidence and the risk of bias were guided and analyzed according to our statistical staff.

Meta-analysis

Statistical analysis was performed using the Cochrane RevMan 5 version 5.4 software (Cochrane Collaboration, Oxford, UK) that was updated in May 2020. Continuous variables were calculated by mean difference (MD) and 95% confidence interval (CI) using a random effect with inverse variance while the risk of difference (RD) and 95% CI for dichotomous variables were calculated using the Mantel-Haenszel method with a fixed effects model.
Heterogeneity was calculated using the Higgins method (I²). The values <45% were considered as low heterogeneity, 46-75% as moderate heterogeneity, and >75% as high heterogeneity. For the analyses, the mean, standard deviation, and absolute numbers were considered. When we had no means or standard deviations, they were calculated using mathematical equations [23]. P values ≤0.05 were considered statistically significant.
Study selection
When we placed the terms of our search strategy in the selected databases, 644 studies were identified. After analysis and confirmation of all the databases, duplicate articles were discarded, which were verified by titles and abstract comprising 522 articles, of which 46 were subsequently selected for manual verification of the complete literature. After the analysis of complete articles, seven studies were selected, of which two were excluded because they were not randomized controlled studies. Finally, we included five RCTs [24–28] for analysis (Fig. 1).
Study characteristics
Five RCTs [24–28] were included and 358 patients were identified: 178 in the CO2 insufflation group and 180 in the air insufflation group. The characteristics of the individual studies are listed in Table 1.
Risk of bias
On assessment of the risk of bias, the studies by Dike et al. [24], Dharmarj et al. [25], and Kresz et al. [26] were considered low risk, whereas the studies by Thornhill et al. [27] and Homan et al. [28] had some concerns . Risk of bias was assessed globally and by outcomes (Supplementary File 1).
Quality of evidence - GRADEpro
The estimated outcome of procedure time demonstrated low-quality evidence. Abdominal pain immediately post-procedure showed high quality of evidence, while that at 24 hours after the procedure showed low quality of evidence (Supplementary File 2).

Synthesis of results and results of individual studies

Procedure time
Four studies [24–26,28] in which 256 patients were included (CO2 insufflation group, n=127; air insufflation group, n=129) reported the procedure time. In the statistical analysis, no statistical significance was shown between groups (MD, 10.84; 95% CI, -2.55 to 24.22; p=0.11)(Fig. 2, Supplementary Fig. 1).
Abdominal pain immediately post-procedure
Three studies [25–27] with a total of 213 patients (CO2 insufflation group, n=107; air insufflation group, n=106) reported the incidence of immediate abdominal pain post-colonoscopy. Abdominal pain was significantly higher in the air insufflation group than in the CO2 insufflation group (RD, -0.15; 95% CI, -0.26 to 0.03; p=0.01)(Fig. 3A, Supplementary Fig. 2).
Abdominal pain at 24 hours post-procedure
Three studies [25,27,28] with 216 patients (CO2 insufflation group, n=106; air insufflation group, n=110) reported adverse events of abdominal pain at 24 hours after colonoscopy. Statistical analysis did not show statistical significance between groups (RD, -0.05; 95% CI, -0.11 to 0.01; p=0.11) (Fig. 3B, Supplementary Fig. 3).
The role of colonoscopy in pediatric patients should include careful consideration of individual patient preference, be performed in a collaborative friendly environment, ensure the use of appropriate equipment, and be performed by a trained pediatric endoscopist [1,18,29]. However, despite ensuring the most appropriate techniques and maneuvers during the procedure, colonoscopy may sometimes be associated with discomfort, mainly abdominal pain or bloating as a result of accumulation of gases used for insufflation. As such, the use of CO2, which is absorbed from the intestine into the blood 13 times faster than oxygen and 160 times faster than nitrogen may have distinct advantages over traditional air insufflation [30]. In addition to having high diffusibility, CO2 may be easily excreted by the lungs, reducing gas volume after colonoscopy, allowing the intestine to decompress more quickly and potentially decrease intraprocedural and post-procedure pain [13,31,32], which is why insufflation with ambient air is increasingly being replaced by CO2.
We decided to conduct the first systematic review with meta-analysis comparing the benefits of CO2 versus ambient air insufflation during pediatric colonoscopy. In this study, we included five RCTs [24–28] with good quality and adequate methodological design, including 358 pediatric patients. Furthermore, it was found that there was no statistical difference in terms of colonoscopy time, demonstrating that the type of gas used during the procedure does not influence the duration of the procedure. Additionally, based on this meta-analysis, post-procedure pain was also analyzed and CO2 insufflation showed clinical advantage in terms of reducing immediate post-colonoscopy abdominal pain in children.
These results are similar to those of several previous meta-analyses analyzing CO2 and air insufflation use in endoscopic procedures in adult patients [13,31,33,34]. Despite this evidence, variable results have been found in pediatrics. In a pediatric study by Dharmaj et al. 2020 [25], multivariate analyses adjusted for baseline pain in children showed that CO2 insufflation only improved post-procedure pain in those patients with a history of abdominal pain, previous abdominal surgery, and procedures longer than 30 minutes. However, Dike et al. [24] demonstrated minimal benefits in favor of CO2 in any pediatric endoscopic procedure. In a recent guideline published in 2020, Rogers et al. [34] evaluated 23 RCTs in adult patients undergoing colonoscopy to compare CO2 versus air insufflation and found that patients who underwent colonoscopy with air insufflation had 30% higher intra-procedural pain scores than those who received CO2 insufflation. This study also demonstrated a sustained benefit in the CO2 group at 30 minutes, 1-2 hours, and 6 hours after the procedure (p<0.001), as well as less abdominal distension, bloating, and flatulence.
While not assessed in our meta-analysis, four studies specifically evaluated abdominal bloating [24–26,28], showing no significant difference in bloating with CO2 versus ambient air insufflation during pediatric colonoscopy. This result is divergent from those analyzing adult patients, who demonstrated objectively decreased abdominal bloating post-procedure [34]. While the mechanism for this difference remains unclear, it is worth noting that both groups of patients, children and adults, measured bloating via a tape measure to assess abdominal circumference. This crude, likely inaccurate method to assess bloating may explain these differences. Moreover, there are other more precise methods to measure bloating (i.e., validated questionnaires) or abdominal circumference, such as radiological measures; however, radiation exposure is not justifiable.
This meta-analysis did not find a significant difference in abdominal pain 24 hours post-colonoscopy between groups. However, the included studies assessed pain through telephone calls and questioning of the family members, thereby increasing the risk of bias. Several meta-analyses from adult populations have demonstrated decreased patient discomfort with CO2 insufflation, and therefore its use has been recommended in the British and European endoscopy guidelines for colonoscopy in adults [35–37]. However, to date, pediatric endoscopy societies have not adopted CO2 insufflation into formalized guidelines, likely due to the low quality of evidence [1]. The results obtained from this meta-analysis and systematic review, including only RCTs showed that the use of CO2 reduces post-procedure pain; we believe that future guidelines may recommend the use of CO2 as a preferred approach for colonoscopy procedures in the pediatric population.
Although this meta-analysis only included RCTs, our study is not without limitations. First, some patients included in this study underwent same-session upper digestive endoscopy in some cases using ambient air or CO2 for insufflation, which may interfere with the quantity of gas within the gastrointestinal lumen as well as alter the procedure time depending on the technique used to perform the colonoscopy, according to an experienced endoscopist or pediatric gastroenterology fellows. Second, the study by Dike et al. [24] specifies the procedure time: only for upper digestive endoscopy, upper digestive endoscopy plus colonoscopy, and colonoscopy alone; taking into account that our meta-analysis included only colonoscopy, it is necessary for our evaluation to extract data only from the said procedure. Additionally, heterogeneity in trial design and lack of standardization in pain scales may also impact these results. Abdominal pain in the included studies was assessed using various pain scales, both numerical analog and visual, both of which are subjective measurements, thus promoting a heterogeneous analysis as most infants and young children cry before or after medical procedures by emotional stress of being with the healthcare staff, being in a different place or due to past traumatic experience and not necessarily related to the pain of the procedure. Additionally, procedural sedation may also impact the degree of post-procedure pain. Although procedural comfort and postprocedural pain are and should remain the most relevant outcomes of interest among a population of pediatric patients, a cost-effectiveness analysis of CO2 versus air insufflation may also be helpful to practitioners. Furthermore, although this meta-analysis included pediatric patients, patient age was over 10 years, necessitating more studies to specifically examine the impact of different insufflations in younger individuals. Lastly, despite the inclusion of five studies, not all studies provided relevant data for the measured outcomes of this meta-analysis. Nevertheless, this study is the first systematic review and meta-analysis to assess CO2 versus air insufflation during colonoscopy in a pediatric setting. Furthermore, the study was performed following the PRISMA guidelines and Cochrane working methodology.
In conclusion, CO2 insufflation significantly reduced the amount of post-procedure abdominal pain following colonoscopy. When compared to air insufflation for colonoscopy among a group of pediatric patients, immediate abdominal pain was decreased for patients undergoing CO2, with no change in procedure time or pain at 24 hours post-procedure. These findings suggest that CO2 insufflation should be the method of choice in pediatric colonoscopy.

Supplementary File 1.

Overall risk of bias.
ce-2020-275-suppl1.pdf

Supplementary File 2.

GRADEpro. Supplementary file.
ce-2020-275-suppl1.pdf

Supplementary Fig. 1.

Funnel plot - Procedure time. MD, mean difference; SE, standard error
ce-2020-275-suppl2.pdf

Supplementary Fig. 2.

Funnel plot - Abdominal pain immediately post-procedure. RD, the risk of difference; SE, standard error.
ce-2020-275-suppl2.pdf

Supplementary Fig. 3.

Funnel plot - Abdominal pain at 24 hours post-procedure. RD, the risk of difference; SE, standard error
ce-2020-275-suppl2.pdf

Conflicts of Interest: Eduardo Guimarães Hourneaux de Moura received personal fees from Boston Scientific and Olympus, outside the submitted work. The other authors have no potential conflicts of interest.

Funding

None.

Author Contributions

Conceptualization: John Alexander Lata Guacho, Diogo Turiani Hourneaux de Moura, Igor Braga Ribeiro

Data curation: JALG, DTHM, IBR, Bruna Furia Buzetti Hourneaux de Moura, Megui Marilia Mansilla Gallegos, Thomas McCarty, Ricardo Katsuya Toma

Formal analysis: JALG, DTHM, IBR, TM

Methodology: JALG, DTHM, IBR, TM

Project administration: Eduardo Guimarães Hourneaux de Moura

Resources: EGHM

Software: EGHM

Supervision: DTHM, EGHM

Validation: DTHM, IBR, EGHM

Visualization: DTHM, IBR, EGHM

Writing-original draft: JALG, DTHM, IBR, MMMG

Writing-review and editing: JALG, IBR

Fig. 1.
Flow diagram of the analyzed studies.
ce-2020-275f1.jpg
Fig. 2.
Forest plot comparing the time of the colonoscopy procedure, using CO2 insufflation versus air insufflation in pediatric patients. CI, confidence interval; IV, instrumental variable; SD, standard deviation.
ce-2020-275f2.jpg
Fig. 3.
(A) Forest plot comparing abdominal pain immediately post-procedure using CO2 insufflation versus air insufflation in pediatric patients. (B) Forest plot comparing abdominal pain at 24 hours after the procedure, using CO2 insufflation versus air insufflation in pediatric patients. CI, confidence interva.
ce-2020-275f3.jpg
Table 1.
Characteristics of Included Studies
Study Country Study type Blinding Age (yr) Population (n) Participants (CO2/Air) Sedation and analgesia Indications for colonoscopy
Dike et al. (2020) [24] USA RCT Double 6 months to 21 69 33/36 Propofol and general anesthesia administered by pediatric anesthesiologist. Abdominal pain, diarrhea, hematochezia, feeding or growth concerns, other.
Dharmarj et al. (2020) [25] USA RCT Double 8 – 21 100 48/52 General anesthesia administered by pediatric anesthesiologist. Sevoflurane and propofol was used to obtain a level of deep sedation during the procedure. Chronic abdominal pain and non-abdominal pain.
Kresz et al. (2019) [26] Germany RCT Double 4 – 17 73 39/34 Midazolam, propofol and narcotics (alfentanil, remifentanil, ketamine) were administered by an anesthesiologist to maintain deep sedation. Inflammatory bowel disease (active disease, evaluation of therapy effectiveness), chronic abdominal pain, diarrhea, hematochezia and other.
Thornhill et al. (2017) [27] USA RCT Double 5 – 18 40 20/20 General anesthesia administered by pediatric anesthesiologist. Abdominal pain, bleeding, diarrhea, surveillance for inflammatory bowel disease, anemia, weight loss and other.
Homan et al. (2016) [28] USA RCT Double 7 – 18 76 38/38 Midazolam, ketamine. Chronic diarrhea, chronic abdominal pain, suspicion of inflammatory bowel disease, inflammatory bowel disease therapy effectiveness evaluation, hematochezia, rectal prolapse and malabsorption syndrome.

RCT, randomized control trial.

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Figure & Data

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    • Elevations in End-Tidal CO2 With CO2 Use During Pediatric Endoscopy With Airway Protection: Is This Physiologically Significant?
      Chinenye R. Dike, Andrew Huang Pacheco, Elizabeth Lyden, David Freestone, Ojasvini Choudhry, Warren P. Bishop, Mohanad Shukry
      Journal of Pediatric Gastroenterology & Nutrition.2023; 76(5): 660.     CrossRef

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      Insufflation of Carbon Dioxide versus Air During Colonoscopy Among Pediatric Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
      Clin Endosc. 2021;54(2):242-249.   Published online March 25, 2021
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    Insufflation of Carbon Dioxide versus Air During Colonoscopy Among Pediatric Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
    Image Image Image
    Fig. 1. Flow diagram of the analyzed studies.
    Fig. 2. Forest plot comparing the time of the colonoscopy procedure, using CO2 insufflation versus air insufflation in pediatric patients. CI, confidence interval; IV, instrumental variable; SD, standard deviation.
    Fig. 3. (A) Forest plot comparing abdominal pain immediately post-procedure using CO2 insufflation versus air insufflation in pediatric patients. (B) Forest plot comparing abdominal pain at 24 hours after the procedure, using CO2 insufflation versus air insufflation in pediatric patients. CI, confidence interva.

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