Clin Endosc > Volume 55(3); 2022 > Article
Siripoppohn, Pittayanon, Tiankanon, Faknak, Sanpavat, Klaikaew, Vateekul, and Rerknimitr: Real-time semantic segmentation of gastric intestinal metaplasia using a deep learning approach



Previous artificial intelligence (AI) models attempting to segment gastric intestinal metaplasia (GIM) areas have failed to be deployed in real-time endoscopy due to their slow inference speeds. Here, we propose a new GIM segmentation AI model with inference speeds faster than 25 frames per second that maintains a high level of accuracy.


Investigators from Chulalongkorn University obtained 802 histological-proven GIM images for AI model training. Four strategies were proposed to improve the model accuracy. First, transfer learning was employed to the public colon datasets. Second, an image preprocessing technique contrast-limited adaptive histogram equalization was employed to produce clearer GIM areas. Third, data augmentation was applied for a more robust model. Lastly, the bilateral segmentation network model was applied to segment GIM areas in real time. The results were analyzed using different validity values.


From the internal test, our AI model achieved an inference speed of 31.53 frames per second. GIM detection showed sensitivity, specificity, positive predictive, negative predictive, accuracy, and mean intersection over union in GIM segmentation values of 93%, 80%, 82%, 92%, 87%, and 57%, respectively.


The bilateral segmentation network combined with transfer learning, contrast-limited adaptive histogram equalization, and data augmentation can provide high sensitivity and good accuracy for GIM detection and segmentation.


Gastric intestinal metaplasia (GIM) is a well-known premalignant lesion and a risk factor for gastric cancer.1 Its diagnosis is highly challenging due to subtle mucosal changes that can be easily overlooked. White light endoscopy (WLE) alone, when observed by less experienced endoscopists, may lead to premalignant lesions from normal mucosa being missed.2,3 Various techniques have been developed to enhance the detection rate of these lesions, including the multiple random biopsy protocol (Sydney protocol)4 and image-enhanced endoscopy (IEE), including narrow-band imaging (NBI), blue light imaging, linked color imaging, iScan, and confocal laser imaging.5-7 Random biopsy for histological evaluation is generally cost prohibitive. IEE diagnosis entails a significant time requirement for training endoscopists to achieve high accuracy in GIM interpretation. Unlike colonic polyps, segmentation of GIM is difficult to define because it usually has an irregular border with many scattered lesions. Segmentation of GIM can become very difficult and often results in poor results when performed by less experienced endoscopists.8
Deep learning models (DLMs) have made dramatic entrances into the field of medicine. One of the most popular research objectives in upper gastrointestinal (GI) endoscopy is to detect and segment early gastric neoplasms.9,10 Among the publicly available models, DeepLabV3+11 and U-Net12 are considered state-of-the-art DLMs for segmentation tasks. However, these models cannot be integrated in a real-time system that requires at least 25 frames per second (FPS)13; this is because of the significant computation requirements for high-resolution images, which result in delays and sluggish displays of the captured areas during real-time endoscopy.
Rodriguez-Diaz et al.14 applied DeepLabV3+ to detect colonic polyps and achieve an inference speed (IFS) of only 10 FPS. Wang et al.15 applied DeepLabV3+ to segment gastrointestinal metaplasia and found that the IFS was only 12 FPS. In addition, Sun et al.16 employed U-Net to detect colonic polyps and reached a speed close to the threshold IFS (22 FPS). However, the image size was still relatively small (384×288 pixels) when compared with the much larger image in the current standard practice (1,920×1,080 pixels). Findings from our earlier experiments with U-Net revealed that the IFS was only three FPS in the current standard image size. In addition, the detection performances of many DLMs are still limited owing to the availability of only a handful of training GIM datasets. The suboptimal supply of medical images might cause low accuracy in the model, leading to poor practice performance. Therefore, additional techniques to improve DLM accuracy, including transfer learning (TL),17 image enhancement, and augmentation (AUG), may be necessary.
This study aimed to establish and implement a new DLM with additional techniques (TL, image enhancement, and AUG) that could produce a more practical real-time semantic segmentation with high accuracy to detect GIM during upper GI endoscopy.


Study design and participants

A single-center prospective diagnostic study was performed. We trained and tested our DLMs to detect GIM using WLE and NBI using data from the Center of Excellence for Innovation and Endoscopy in Gastrointestinal Oncology, Chulalongkorn University, Thailand. Informed consent for the endoscopic images was obtained from consecutive GIM patients aged 18 years or older who underwent upper endoscopy under WLE and/or IEE between January 2016 and December 2020. We assigned the pathological diagnosis as a ground-truth diagnosis. Two pathologists from King Chulalongkorn Memorial Hospital made pathological assessments of specimens obtained from different biopsy stomach sites in at least five areas: two antrums, two bodies, and one incisura, according to the updated Sydney System. Patients with a history of gastric surgery or otherwise diagnosed with other gastric abnormalities such as erosive gastritis, gastric ulcers, gastric cancer, high-grade dysplasia, low-grade dysplasia, and those without a confirmed pathological diagnosis were excluded.

Endoscopy and image quality control

All images were recorded using an Olympus EVIS EXERA III GIF-HQ190 gastroscope (Olympus Medical Systems Corp., Tokyo, Japan). Two expert endoscopists (RP and KT) with a minimum of 5 years of experience in gastroscopy and a minimum of 3 years of experience in IEE and had performed more than 200 GIM diagnoses were selected to review all images. Poor-quality images, which consisted of halation, blur, defocus, and mucus, were removed. The size of the raw images was 1,920×1,080 pixels, and they were stored in a joint photographic expert group (JPEG) format. All images were cropped to show only the gastric epithelium (nonendoscopic images and other labels such as patient information were removed), resulting in an image with 1,350×1,080 pixels.

Image datasets

After the biopsy-proven GIM images were obtained, with unanimous agreement, two expert endoscopists (RP and KT) performed annotations on the images to define GIM segments using LabelMe.18 The labeled images were stored in portable network graphics (PNG) format and referred to as ground-truth images. Data were stratified by the type of image to ensure that the proportion between white light and NBI images was maintained. The labeled GIM images were separated into three datasets. Seventy percent of the expected total GIM images were used as the training set, 10% were assigned for validation, and 20% served as the test dataset.
In addition to GIM images, an equal number of non-GIM gastroscopy images were also included in the test set to represent a realistic situation and to evaluate the results on non-GIM images. In these non-GIM frames, no annotations were made, except for cropping of the nonendoscopic areas.

Model development

Four main modules, including three preprocessing modules and one model training module, were used to improve the accuracy of our DLM (Fig. 1). First, the concept of TL was employed to overcome the small training size issue of GIM.17 We utilized 1,068 colonic-polyp images from public datasets (CVC-Clinic19 and Kvasir-SEG20), as shown in Supplementary Figure 1, to pretrain the model to allow the DLM to learn from the GIM dataset more effectively (Supplementary Table 1).
Second, and similar to IEE, each GIM image was enhanced by using contrast-limited adaptive histogram equalization (CLAHE) to amplify the contrast of the GIM regions (Supplementary Fig. 2).21 Third, multiple data AUG tricks were applied to create data variations. Nine AUG tricks were employed, including flips (horizontal and vertical), rotations (0°–20°), sharpening, adding of noise, transposition, shift scale rotations, blur, optical distortions, and grid distortions. This step was aimed at increasing the training size, preventing overfitting, and making the model more robust (Supplementary Fig. 3).
Finally, a bilateral segmentation network (BiSeNet)22 specifically designed for real-time segmentation using a much smaller model was applied on top of the pretrained model containing both the enhanced and augmented GIM images to achieve an IFS greater than 25 FPS.13 Two baseline models (DeepLabV3+11 and U-Net12) were also used to analyze the datasets and serve as benchmark models (Supplementary Fig. 4).

Performance evaluation

The model’s performance was evaluated by an internal test in regards to two aspects: (1) GIM detection (the whole frame) and (2) GIM area segmentation (labeling the gastric mucosa area containing GIM). For GIM detection, true positives were classified when the prediction and the ground-truth regions in the GIM images overlapped by greater than 30%. True negatives were assigned when the size of the predicted region covered less than 1% of the non-GIM areas. The model validity was analyzed using metrics including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy.
Segmentation performance was evaluated by the mean intersection over union (mIoU) areas, as shown in Figure 2. For non-GIM images, we calculated the surplus area that was incorrectly predicted as the GIM area. This was defined as the “errors.” IFS, a crucial measure that must be greater than 25 FPS in order for the model to create inferences in real time, was evaluated using FPS. The test dataset was assessed using each model. BiSeNet22 was used as the main model, with additional TL,17 CLAHE,21 and AUG techniques. We used four versions of our new models (BiSeNet alone, BiSeNet+TL, BiSeNet+TL+CLAHE, and BiSeNet+TL+CLAHE+AUG) in the test dataset. Two benchmark models (DeepLabV3+11 and U-Net12) were also tested on the same dataset to compare the model performance (Fig. 3).

Statistical analysis

For the classification result, McNemar test was conducted to compare agreement and disagreement between our model and each baseline. For the segmentation results, a paired t-test was conducted for each image. For the IFS, a paired t-test was also computed to compare the run time of each round (five rounds total).

Ethical statements

The Institutional Review Board of the Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand has approved this study in compliance with the International Guidelines for Human Research Protection in the Declaration of Helsinki, the Belmont Report, CIOMS guidelines, and the International Conference on Harmonization in Good Clinic Practice (ICH-GCP; COA 1549/2020; IRB number 762/62). The protocol was registered at (NCT04358198).


We collected and labeled 802 biopsy-proven GIM images from 136 patients between January 2016 and December 2020 from the Center of Excellence for Innovation and Endoscopy in Gastrointestinal Oncology, Chulalongkorn University, Thailand. A total of 318 images were obtained from WLE, and 484 were NBI. Two expert endoscopists (RP and KT) performed annotations on the images to define GIM segments using labeling software, LabelMe,18 with unanimous agreement. Labeled GIM images were randomly separated into training (70%, 560 images), validation (10%, 82 images), and testing (20%, 160 images) datasets (Table 1). The test dataset also included 160 non-GIM gastroscopy images, which included 137 WLE and 23 NBI images.

GIM diagnostic performance

Using the images from both WLE and NBI, BiSeNet combined with three additional preprocessing techniques (TL, CLAHE, and AUG) showed the highest sensitivity (93.13%) and NPV (92.09%) when compared to BiSeNet alone and BiSeNet without full preprocessing techniques. The diagnostic specificity, accuracy, and PPV of BiSeNet+TL+CLAHE+AUG were 80.0%, 86.5%, and 82.3%, respectively. The overall performance of our proposed model (BiSeNet+TL+CLAHE+AUG) was significantly better than those of DeepLabV3+ and U-Net (p<0.01 for all parameters). The results for all six models are presented in Table 2.
The diagnostic performances of BiSeNet+TL+CLAHE+AUG when using WLE images alone (Table 3) was lower than that of NBI images alone (Table 4) in all modalities, including specificity (78.8% vs. 86.9%), accuracy (80.8% vs. 95.2%), and PPV (62.3% and 97.1%). Furthermore, the overall performance of BiSeNet+TL+CLAHE+AUG from either WLE or NBI images was significantly better than the benchmarks DeepLabV3+ and U-Net (p<0.01 for all parameters) (Tables 3, 4).

GIM segmentation performance

BiSeNet with three preprocessing models showed the highest mIoU in segmenting GIM areas (57.04%±2.75%) compared to BiSeNet alone and BiSeNet without full preprocessing techniques (mIoU 45.94%±3.07% for BiSeNet alone; 47.29%±3.18% for BiSeNet+TL; and 54.94%±2.90% for BiSeNet+TL+CLAHE), with an error of less than 1% (0.96%). When compared to the benchmark models DeepLabV3+ and U-Net, the mIoU of BiSeNet with the three combinations was significantly better (mIoU 57.04%±2.75% for BiSeNet+TL+CLAHE+AUG; 49.22%±3.06% for DeepLabV3+; and 53.02%±2.99% for U-Net; p<0.01 in all parameters) (Table 5).
The segmentation performance of BiSeNet+TL+CLAHE+AUG when using WLE images alone (Supplementary Table 2) was lower than that using NBI images alone (Supplementary Table 3), 52.94% vs. 59.25% in terms of mIoU. Moreover, the overall performance of BiSeNet+TL+CLAHE+AUG using either WLE or NBI images was significantly better than that of DeepLabV3+ and U-Net (p<0.01) (Supplementary Tables 2, 3).

Inference speed

The IFS of BiSeNet+TL+CLAHE+AUG was 31.53±0.10 FPS. BiSeNet alone and all BiSeNet combinations with preprocessing models achieved an IFS greater than the 25 FPS threshold. The IFS of the benchmark models, DeepLabV3+ and U-Net, reached only 2.20±0.01 and 3.49±0.04, respectively (Table 6).
To explore the ability of our model to segment GIM areas in a real-time clinical setting, we tested the model on a WLE video (Supplementary Video 1). In the video clip, the model successfully segmented the GIM lesions correctly without any sluggishness.


The suspicion of GIM based on artificial intelligence (AI) readings may facilitate targeted biopsy. In particular, since unnecessary endoscopic biopsy can be avoided, AI methods would be useful for patients at risk of bleeding, such as those with coagulopathy or platelet dysfunction or those taking antithrombotic agents. Techniques using deep learning for the detection and analysis GI lesions using convolutional neural networks23 have rapidly evolved.24 The two primary objectives for DLM are detection and diagnosis (CADe/CADx). Earlier DLMs for GI endoscopy have been successfully employed on the lower GI tract (e.g., colonic-polyp classification, localization, and detection). DLM employed on the colon achieved a real-time performance with a very high sensitivity (>90%).25
There have been many attempts to use DLM to detect upper GI lesions, including gastric neoplasms, while performing upper GI endoscopy; however, most studies have focused on detecting gastric cancer.26-29 Unlike colonic polyps that require only CADe/CADx, GIM requires more precise segmentation because it usually contains irregular borders with many satellite lesions. None of the current DLMs could achieve the expected level of real-time segmentation because the IFS was still too slow. Xu et al.30 used four DLMs, including ResNet-50,31 VGG-16,32 DenseNet-169,33 and EfficientNet-B4,34 and demonstrated their GIM detection capabilities; however, the endoscopist still had to freeze the image in order to segment the GIM area. This is not practical when performing a real-time upper GI endoscopy.30 In addition, their DLMs were mainly used for interpreting NBI images rather than WLE images, which is usually the preferred mode during initial endoscopy.
Our study showed that by adding all three preprocessing techniques (TL, CLAHE, and AUG) to the BiSeNet model, the new DLM could achieve a sensitivity and NPV higher than 90% for detecting GIM using both WLE and NBI images while maintaining an IFS faster than the 25 FPS threshold.
BiSeNet is a recent real-time semantic segmentation tool that balances the need for accuracy with an optimum IFS. Using BiSeNet alone, the IFS was ten times faster than the two other baseline models, DeepLabV3+ and U-Net (34.02 vs. 2.20 and 3.49% FPS), with comparable performance in terms of classification and segmentation. Despite the impressive speed, the sensitivity and NPV of BiSeNet alone for GIM detection was only 82% and 83%, respectively. Hence, it could not pass the threshold recommended by the Preservation and Incorporation of Valuable Endoscopic Innovations (PIVI) standards for diagnostic tools that require an NPV>90%.35 Therefore, additional preprocessing methods such as TL, CLAHE, and AUG are required to improve model validity, especially the NPV.
While the number of GIM images in our database was limited, the upper GI images shared common characteristics with colonoscopic images in terms of color and texture, allowing the colonoscopic images to be utilized for TL. By adding 2,680 colonoscopic images, TL increased the specificity of the model from 87% to 92%, although the NPV remained lower than the 90% threshold.
The biggest improvement in our DLM can be credited to the application of CLAHE. The detection sensitivity improved by almost 10% (from 82% to 89%), and the mIoU increased by 9% points (from 46% to 55%). This is probably due to the large number of WLE images in our training data, which provided robust image enhancement. Because CLAHE enhances small details, especially textures and local contrast, it can amplify WLE image contrast similar to IEE technology. This is promising for achieving high efficacy in our DLM on WLE images without the need for the NBI mode during real-time endoscopy.
AUG also further improved the sensitivity compared to the previous model by 4% (from 89% to 93%) and increased the mIoU by 2% (from 55% to 57%). Among all three preprocessing methods, TL seemed to show the least benefit. We believe that this may be caused by the differences in the backgrounds of the pretraining colon datasets when compared to the GIM dataset. In retrospect, other upper GI images of disorders such as hemorrhagic gastritis, gastric ulcer, and gastric cancer should have been used instead of just colon images.
Our study illustrated that when using BiSeNet alone, the IFS (31.53±0.10) was faster than the minimum requirement for a real-time performance of 25 FPS. Although the model might have a comparable sensitivity to the two original benchmarks, DeepLabV3+ and U-Net (81.88% vs. 83.75% and 87.50%, respectively), the specificity of BiSeNet was significantly higher than that of the two baselines (87.50% vs. 70.00% and 62.50%, respectively; p<0.01). By adding the three techniques of TL, CLAHE, and AUG, we demonstrated a significant improvement in validities across the board. Importantly, the high NPV for GIM diagnosis in our model (92.09%) exceeded the acceptable performance threshold outlined by PIVI as a screening endoscopy tool. Notably, the other DLMs did not reach the threshold number.
For the GIM segmentation, our DLM produced an mIoU of 57.04%, which is considerably lower than that of a substantial mIoU. Since GIM typically presents as scattered lesions in the same area, we believe that correct segmentation on more than half of all GIM lesions is sufficient for the endoscopists to perform targeted biopsy and to provide the correct recommendation regarding the frequency of endoscopic surveillance from the extension of GIM. For example, the British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma recommend an interval of endoscopic surveillance according to the extension of GIM.36 An interval of 3 years is recommended for patients with extensive GIM, defined as that affecting both the antrum and body. For patients with GIM limited to only the antrum, the risk of gastric cancer development is very low; therefore, further surveillance is not recommended.36
The key breakthrough of this study is that, for the first time, a DLM has been able to achieve an IFS speed that is fast enough to perform real-time GIM segmentation. Our full DLM could also detect and segment GIM areas from both WLE and NBI images. We believe that our DLM is more practical for endoscopists who usually perform initial endoscopy with WLE and then switch to NBI mode for detailed characterization after a lesion is detected. We also feel that our DLM may aid less experienced endoscopists in locating more suspected GIM areas during WLE, considering that they can switch to NBI mode after being notified by the DLM to further examine the suspected GIM areas more efficiently.
The findings of this study must be tempered with several limitations that could impact the successful replication and real-time success of our model. First, we retrieved the GIM images from one endoscopy center using a single endoscope model. To address the issue of dataset quality and increase the generalizability of results, images from other endoscopy centers and endoscope models with different IEE modes, including iScan, blue light imaging, and linked color imaging, are needed. Second, this model has not been fully studied in a real-time setting. Our preliminary test showed that it could function well without sluggish frames. Most importantly, endoscopists did not need to freeze the video to produce the still image for the DLM analysis (Supplementary Video 1). Third, we excluded other endoscopic findings, including hemorrhagic gastritis, gastric ulcer, and gastric cancer, as well as retained food content, bubbles, and mucous from our datasets. Therefore, our model may return more errors when analyzing lesion images. However, we feel that in real-time procedures, endoscopists should easily distinguish between these abnormalities and the actual suspected GIM areas. Finally, the results of this study were based on an internal test that lacked external validation. Nevertheless, we plan to conduct an external validation test to prove the results of this study in the near future.
In conclusion, compared with the benchmark models DeeplabV3+ and U-Net, the BiSeNet model in combination with three techniques (TL, CLAHE, and data AUG) significantly improved GIM detection while maintaining a fair quality of segmentation (mIoU>50%). With the IFS reaching 31.53 FPS in this model, these results pave the way for future research on real-time GIM detection during upper GI endoscopy.

Supplementary Material

Supplementary Video 1. The model was tested on a real video during an esophagogastroduodenoscopy. It successfully captured the gastric intestinal metaplasia lesions in real time (
Supplementary Fig. 1. Examples of colonoscopy images for transfer learning.
Supplementary Fig. 2. Images pre- and postprocessed by CLAHE.
Supplementary Fig. 3. Examples of the nine data augmentation techniques applied to each gastric intestinal metaplasia image.
Supplementary Fig. 4. Model architecture of the BiSeNet.
Supplementary Table 1. Images and resolution of each dataset for transfer learning.
Supplementary Table 2. Segmentation performance of two baseline models (DeepLabV3+ and U-Net) compared to four BiSeNet family models focused on white light endoscopy images.
Supplementary Table 3. Segmentation performance of two baseline models (DeepLabV3+ and U-Net) compared to four BiSeNet family models focused on narrow-band imaging images.
Supplementary materials related to this article can be found online at


Conflicts of Interest
The GPUs used in this project were sponsored by an NVIDIA GPU grant in collaboration with Dr. Ettikan K Karuppiah, a director/technologist at NVIDIA, Asia Pacific South Regions. The authors have no other conflicts of interest to declare.
This research was funded by the National Research Council of Thailand (NRCT; N42A640330), Chulalongkorn University (CU-GRS-64), and Chulalongkorn University (CU-GRS-62-02-30-01) and supported by the Center of Excellence in Gastrointestinal Oncology, Chulalongkorn University annual grant. It was also funded by the University Technology Center (UTC) at Chulalongkorn University.
Author Contributions
Conceptualization: RP, PV, RR; Data curation: VS, RP, KT, NF, AS, NK; Formal analysis: VS, RP, KT, PV, RR; Funding acquisition: PV, RR; Methodology: RP, PV, RR; Writing–original draft: VS, KT; Writing–review & editing: RP, PV, RR. All authors read and approved the final manuscript.

Fig. 1.
The proposed framework of our study. GI, gastrointestinal; CLAHE, contrast-limited adaptive histogram equalization; BiSeNet, bilateral segmentation network.
Fig. 2.
Examples of intersection over union (mIoU) evaluation on a gastric intestinal metaplasia image. (A) IoU=0.8, (B) IoU=0.6, (C) IoU=0.4. Red indicates a ground-truth region. Blue indicates a predicted region. Green demonstrates the intersected area.
Fig. 3.
Prediction examples in six images, where the green circle encloses the gastric intestinal metaplasia (GIM) area. (A) Raw image, (B) ground-truth, and (C) prediction by BiSeNet alone, and (D) prediction by our full model (BiSeNet+TL+CLAHE+AUG). Rows 1–4 represent GIM images, and rows 5–6 represent non-GIM images. BiSeNet, bilateral segmentation network; TL, transfer learning; CLAHE, contrast- limited adaptive histogram equalization; AUG, augmentation.
Table 1.
Data separation in the gastric intestinal metaplasia dataset
Folder White light image Narrow-band image Total
Training 231 329 560
Validation 31 51 82
Testing 56 104 160
Total 318 484 802
Table 2.
GIM detection performance of two baseline models (DeepLabV3+ and U-Net) compared to four BiSeNet variations
Both WLE and NBI images Sensitivity Specificity PPV NPV Accuracy
 DeepLabV3+ 83.75 70.00 73.63 81.16 76.88
 U-Net 87.50 62.50 70.00 83.33 75.00
Our model
 BiSeNet 81.88 87.50 86.75 82.84 84.69
 BiSeNet+TL 80.00 91.88 85.94 82.12 85.94
 BiSeNet+TL+CLAHE 89.38 73.75 77.30 87.41 81.56
 BiSeNet+TL+CLAHE+AUG 93.13 80.00 82.32 92.09 86.56

Values are presented as percentage.

GIM, gastric intestinal metaplasia; WLE, white light endoscopy; NBI, narrow-band imaging; BiSeNet, bilateral segmentation network; TL, transfer learning; CLAHE, contrast-limited adaptive histogram equalization; AUG, augmentation; PPV, positive predictive value; NPV, negative predictive value.

Table 3.
GIM detection performance of two baseline models (DeepLabV3+ and U-Net) compared to four BiSeNet variations, all using WLE images
WLE images alone Sensitivity Specificity PPV NPV Accuracy
 DeepLabV3+ 80.36 68.61 51.14 89.52 72.02
 U-Net 85.71 60.58 47.06 91.21 67.88
Our model
 BiSeNet 78.57 85.40 68.75 90.70 83.42
 BiSeNet+TL 71.43 91.24 76.92 88.65 85.49
 BiSeNet+TL+CLAHE 83.93 72.99 55.95 91.74 76.17
 BiSeNet+TL+CLAHE+AUG 85.71 78.83 62.34 93.10 80.83

Values are presented as percentage.

GIM, gastric intestinal metaplasia; WLE, white light endoscopy; BiSeNet, bilateral segmentation network; TL, transfer learning; CLAHE, contrast-limited adaptive histogram equalization; AUG, augmentation; PPV, positive predictive value; NPV, negative predictive value.

Table 4.
GIM detection performance of two baseline models (DeepLabV3+ and U-Net) compared to four BiSeNet variations, all using NBI images
NBI images alone Sensitivity Specificity PPV NPV Accuracy
 DeepLabV3+ 85.58 78.26 94.68 54.55 84.25
 U-Net 88.46 73.91 93.88 58.62 85.83
Our model
 BiSeNet 83.65 100.00 100.00 57.50 86.61
 BiSeNet+TL 84.62 95.65 98.88 57.89 86.61
 BiSeNet+TL+CLAHE 92.31 78.26 95.05 69.23 89.76
 BiSeNet+TL+CLAHE+AUG 97.12 86.96 97.12 86.96 95.28

Values are presented as ±95% confidence interval.

GIM, gastric intestinal metaplasia; NBI, narrow-band imaging; BiSeNet, bilateral segmentation network; TL, transfer learning; CLAHE, contrast-limited adaptive histogram equalization; AUG, augmentation; PPV, positive predictive value; NPV, negative predictive value.

Table 5.
The segmentation performance of two baselines (DeepLabV3+ and U-Net) compared to four BiSeNet family models
Both WLE and NBI images mIoU for GIM (%) Error for non-GIM (%)
 DeepLabV3+ 49.22±3.06 1.79±0.72
 U-Net 53.02±2.99 1.81±0.53
Our model
 BiSeNet 45.94±3.07 0.46±0.18
 BiSeNet+TL 47.29±3.18 0.33±0.17
 BiSeNet+TL+CLAHE 54.94±2.90 0.98±0.36
 BiSeNet+TL+CLAHE+AUG 57.04±2.75 0.96±0.36

Values are presented as ±95% CI.

BiSeNet, bilateral segmentation network; WLE, white light endoscopy; NBI, narrow-band imaging; mIoU, mean intersection over union; GIM, gastric intestinal metaplasia; CI, confidence interval; TL, transfer learning; CLAHE, contrast-limited adaptive histogram equalization; AUG, augmentation.

Table 6.
The inference speed of the two benchmarks (DeepLabV3+ and U-Net) compared to four BiSeNet family model variations
Method Frames per second
 DeepLabV3+ 2.20±0.01
 U-Net 3.49±0.04
Study model
 BiSeNet 34.02±0.24
 BiSeNet+TL 33.33±0.05
 BiSeNet+TL+CLAHE 31.83±0.31
 BiSeNet+TL+CLAHE+AUG 31.53±0.10

Values are presented as mean±standard deviation.

BiSeNet, bilateral segmentation network; TL, transfer learning; CLAHE, contrast-limited adaptive histogram equalization; AUG, augmentation.


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