| 만성적인 알코올 섭취가 대장 수면내시경시 미다졸람 투여에 미치는 영향 |
| 박영숙·이종용·서유승·김충현·이정돈·이현석·권계형·김태헌·조윤주 |
| 을지의과대학교 노원을지병원 내과학교실 |
| Effects of Chronic Alcohol Consumption on Midazolam Induced Sedation during Colonoscopy |
| Young Sook Park, M.D., Jong Yong Lee, M.D., Yu Seoung Seo, M.D., Chung Hyeon Kim, M.D., Jung Don Lee, M.D., Hyun Suk Lee, M.D., Kye Hyung Kwon, M.D.,Tae Hun Kim, M.D. and Yun Ju Jo, M.D. |
| Department of Gastroenterology, Eulji University School of Medicine, Nowon Eulji Medical Center, Seoul, Korea |
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| Abstract |
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Background/Aims:
It is suggested that patients consuming large amounts of alcohol are difficult to be sedated by midazolam probably due to cross tolerance. We studied to know the adequate administration doses of midazolam in patients with chronic alcohol consumption.
Methods:
Study I; We prospectively studied 117 outpatients presenting for colonoscopy. According to alcohol consumption we divided four groups such as group I: 0 g/day, group II: ＜10 g/day, group III: 10∼40 g/day, group IV: ＞40 g/day. We initially administered 0.06 mg/kg midazolam and add up to spontaneous eye closure. We measured grade of amnesia, level of consciousness, endoscopist's assessment and VAS scale for pain after recovery. Study II; We measured induction time after 0.08 mg/kg midazolam in 60 patients who drink alcohol.
Results:
Additional amount of midazolam was not significantly different between the groups (group I: 0.0145 mg/ kg, group II: 0.0214 mg/kg, group III: 0.0181 mg/kg, group IV: 0.0199 mg/kg). There were no differences of sedation parameters between the groups. However the induction time was prolonged and correlated with alcohol consumption.
Conclusions:
For adequate sedation in patients with chronic alcohol consumption, longer induction time rather than increasing dosage is required. (Korean J Gastrointest Endosc 2004;29:495499) |
| Key Words:
Alcohol, Conscious sedation, Colonoscopy, Midazolam, Induction time |
| 주요어:
알코올, 수면내시경, 미다졸람, 수면유도시간 |
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