Korean Journal of Gastrointestinal Endoscopy 2005;30(3): 133-139.
악성화한 대장선종에서 Cyclooxygenase-2와 p53 단백의 발현
김석현·정재훈·강윤세·김연수·박기오·이엄석·김선문·서승원·성재규·이병석·정현용·송규상*
충남대학교 의과대학 내과학교실, *병리학교실
Expression of Cyclooxygenase-2 and p53 Protein in Colonic Adenoma with Malignant Change
Seok Hyun Kim, M.D., Jae Hoon Jung, M.D., Yoon Sae Kang, M.D., Yeon Soo Kim, M.D., Ki Oh Park, M.D., Yeum Seok Lee, M.D., Seon Mun Kim, M.D., Seung Won Seo, M.D., Jae Kyu Seong, M.D., Byung Seok Lee, M.D., Hyun Yong Jeong, M.D. and Gyu Sang Song, M.D.*
Departments of Internal Medicine and *Pathology, Chungnam National University College of Medicine, Daejeon, Korea
Abstract
Background/Aims: The aim of this study was to investigate the value of expression of COX-2 and p53 protein in colonic adenoma with or without malignant change. Methods: We studied twenty-five cases of colonic adenoma with malignant change and twenty-five cases of colonic adenoma without malignant change treated by colonoscopic polypectomy in Chungnam National University Hospital from January, 1999 to July, 2002. We compared the expression of COX-2 and p53 protein by immunohistochemical stain in both group. Results: In immunohistochemical staining, the expression of COX-2 was demonstrated 68.0% (17 of 25) of colonic adenoma with malignant change and not different with that of colonic adenoma without malignant change. The overexpression of p53 protein was detected immunohistochemically in 88.0% (22 of 25) of colonic adenoma with malignant change and 32% (8 of 25) of colonic adenoma only (p＜0.05). Conclusions: The degree of COX-2 expression was similar in colonic adenoma and colonic adenoma with malignant change, but the expression of p53 in colonic adenoma with malignant change was significantly higher (p＜0.05). These results suggest COX- 2 might operate on early step of adenoma-carcinoma sequence. Also these results remind us that mutation of p53 gene operates on the late step of adenoma-carcinoma sequence. (Korean J Gastrointest Endosc 2005;30:133139)
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