The Value of Endoscopic Ultrasound Guided Fine Needle Aspiration Biopsy in the Differential Diagnosis of Pancreatic Mass

Korean J Gastrointest Endosc > Volume 31(3); 2005 > Article

Korean Journal of Gastrointestinal Endoscopy 2005;31(3): 147-154.

췌장 종괴의 감별 진단에 내시경초음파 유도하 세침흡인생검술의 유용성

차재명*·서동완·이상수·박도현·최정식·주영민·이성구·김명환·민영일*

울산대학교 의과대학 서울아산병원 소화기내과, *동국대학교 의과대학 동국대학교병원 소화기내과

The Value of Endoscopic Ultrasound Guided Fine Needle Aspiration Biopsy in the Differential Diagnosis of Pancreatic Mass

Jae Myung Cha, M.D.*, Dong Wan Seo, M.D., Sang Soo Lee, M.D., Do Hyun Park, M.D., Jung Sik Choi, M.D., Young Min Ju, M.D., Sung Koo Lee, M.D., Myung Hwan Kim, M.D. and Young Il Min, M.D.*

Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, *Department of Internal Medicine, Dongguk University International Hospital, Dongguk University College of Medicine, Goyang, Korea

Abstract

Background/Aims:
Endoscopic ultrasound guided fine needle aspiration (EUS-FNA) is a technique used to distinguish benign and malignant pancreatic mass histologically. The aim of this study was to determine the value and safety of EUS-FNA for the differential diagnosis of pancreatic solid mass.
Methods:
The records of forty patients (M：F=24：16, median age: 56 yr) who underwent EUS-FNA for the diagnosis of pancreatic solid masses between October 2003 and July 2004 were analyzed. Histological findings obtained by EUS-FNA were compared with the final diagnosis. The sensitivity, specificity, overall diagnostic accuracy, and the rate of complication of EUS-FNA were analyzed.
Results:
The sites of the lesions were as follows: pancreatic head, n=20 (50%); body, n=10 (25%); tail, n=7 (18%); multifocal, n=3 (8%). The sensitivity, specificity, accuracy and negative predictive values were 71%, 78%, 73%, and 64%, respectively. The diagnostic accuracy was 90% in body lesions, however 65% in head lesions. Transient abdominal pain occurred in one patient (3%) after the procedure; however, there was no case of severe complication.
Conclusions:
EUS-FNA is shown to be an effective and safe procedure for establishing a tissue diagnosis in patients with solid pancreatic masses. (Korean J Gastrointest Endosc 2005;31:147⁣154)

Key Words: Endoscopic ultrasound guided fine needle aspiration, Pancreatic solid mass

주요어: 내시경초음파 유도하 세침흡인생검술, 췌장고형종괴