Korean Journal of Gastrointestinal Endoscopy 2007;34(1): 19-27.
대장 톱니샘종의 β-catenin, hMLH1, p53, Bcl-2, Bax 및 COX-2 단백 발현
최교원 · 장병익 · 은종렬 · 이정훈 · 배영경* · 김태년
영남대학교 의과대학 내과학교실, *병리학교실
Expression of β-catenin, hMLH1, p53, Bcl-2, Bax and COX-2 in Serrated Adenomas of Colon
Kyo Won Choi, M.D., Byung Ik Jang, M.D., Jong Ryul Eun, M.D., Jung Hoon Lee, M.D., Young Kyung Bae, M.D*. and Tae Nyun Kim, M.D.
Departments of Internal Medicine and *Pathology, Yeungnam University College of Medicine, Daegu, Korea
Abstract
Background/Aims: Serrated adenoma of the colorectum is a recently proposed entity that is characterized by a saw-toothed structure of hyperplastic polyp and also the cytologic atypia of conventional adenoma. In contrast to conventional adenomas, the molecular features of serrated adenomas have been poorly studied. Methods: The expression of β-catenin and the DNA mismatch repair protein hMLH1, apoptosis regulating protein Bcl-2, Bax, p53 and COX-2 were analyzed in 28 serrated adenoma specimens and 28 tubular adenoma specimens. Results: No differences were observed in the frequency of β-catenin loss in the cell membrane between the serrated and tubular adenoma specimens. The frequency of hMLH1 loss was significantly higher in the serrated adenomas than in tubular adenomas (p＜0.05). The frequency of p53 overexpression was not significantly different between the serrated and tubular adenoma specimens. The frequencies of the Bax and Bcl-2 overexpressions were significantly lower in the serrated adenomas than in the tubular adenomas. The COX-2 levels were not different between the serrated and tubular adenomas. In the serrated adenoma specimens, the frequency of Bax overexpression was reduced in the older age group (＞60 years old). In the tubular adenoma specimens, the frequency of p53 overexpression was increased in the dysplastic epithelium. Conclusions: The expressions of hMLH1, Bax and Bcl-2 were decreased in the serrated adenoma than in the tubular adenoma. Our data suggest that the serrated adenoma and tubular adenoma may have different pathway in their development. However, further studies including normal mucosa, hyperplastic polyp and cancer specimens are needed.
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