Korean J Gastrointest Endosc > Volume 37(3); 2008 > Article
Korean Journal of Gastrointestinal Endoscopy 2008;37(3): 161-166.
Helicobacter pylori 재감염과 관련된 임상적 요인에 대한 분석
김재환ㆍ양효준ㆍ장은선ㆍ조은주ㆍ조현진ㆍ천재영ㆍ최종경ㆍ황성욱ㆍ이상협*ㆍ박영수*ㆍ황진혁*ㆍ김진욱*ㆍ정숙향*ㆍ김나영*ㆍ이동호*ㆍ정현채ㆍ송인성
서울대학교 의과대학 내과학교실, 간연구소, *분당서울대학교병원 내과
Clinical Features of Re-infection of Helicobacter pylori after Successful Eradication
Jai Hwan Kim, M.D., Hyo Joon Yang, M.D., Eun Sun Jang, M.D., Eun Ju Jo, M.D., Hyun Jin Jo, M.D., Jae Young Chun, M.D., Jong Kyung Choi, M.D., Sung Wook Hwang, M.D., Sang Hyub Lee, M.D.*, Young Soo Park, M.D.*, Jin Hyeok Hwang, M.D.*, Jin Wook Kim, M.D.*,
Department of Internal Medicine and the Liver Research Institute, Seoul National University College of Medicine, Seoul, *Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
Abstract

Background/Aims:
Studies on re-infection of Helicobacter pylori are limited. This study was designed to determine if there are clinical features of H. pylori re- infection related to gastroduodenal diseases or histological findings.
Methods:
From a population of patients that were treated for H. pylori eradication from May 2003 to September 2007, 129 subjects were enrolled. Regimens were PPI-based triple or quadruple agents and follow-up methods were UBT, CLO or histology.
Results:
A total of 29 subjects experienced a recurrence (within one year, 17 subjects; between one and two years, eight subjects; more than two years, four subjects). Recurrence periods were 2 to 32 months, and the mean period was 12.62± 8.40 months. Among 29 subjects, eight subjects had chronic atrophic gastritis, 14 subjects had a peptic ulcer, five subjects had stomach cancer and two subjects had a MALT lymphoma; there were no statistical differences of the odds ratio between matched diseases. By use of the Updated Sydney System, neither H. pylori colonization density nor neutrophil infiltration nor monocyte infiltration grade in histology was associated with recurrence or re-infection.
Conclusions:
Neither histological findings nor gastroduodenal diseases was associated with H. pylori re-infection. The re-infection rate in this study was approximately 6.2%. This rate was slightly higher than rates reported in other recent studies in Korea. (Korean J Gastrointest Endosc 2008;37:161-166)
Key Words: Helicobacter pylori, Recurrence, Reinfection, Gastroduodenal diseases, Histology
주요어: 헬리코박터, 재발, 재감염, 위장관 질환, 조직학
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